7岁女孩骨龄10岁，乳腺发育，亮丙瑞林刺激试验阴性，下一步该查啥？

患儿， 女，7 岁孩，一次例行检查。体温37 ° C、 脉搏是 70 次/分，呼吸 13 /min，血压97/58 毫米汞柱。体格检查揭示 乳房发育Tanner 3 期。手腕骨X线片示骨龄 10 岁。亮丙瑞林刺激试验显示对促黄体生成激素反应迟钝。

为明确诊断，下列哪一项是最合适？

A.全血细胞计数

B.头颅 CT

C.颅脑 MRI 检查

D.雌二醇浓度测量

E.超声检查卵巢和肾上腺

A 7-year-old girl presents for a routine examination. Her temperature is 98.6°F (37°C), her pulse is 70 beats/min, her respiration rate is 13 breaths/min, and her blood pressure is 97/58 mm Hg. 

Her physical examination reveals Tanner stage 3 breast development. A radiograph of the wrist is obtained and reveals a bone age of 10 years. A leuprolide stimulation test shows no luteinizing hormone response to gonadotropin-releasing hormone (GnRH) agonist stimulation. 

Which of the following is the most appropriate next step in the diagnosis of this patient?

A. Complete blood count

B. Cranial CT

C. Cranial MRI

D. Estradiol concentration measurement

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