转移形式提示鼻咽癌预后
这个帖子发布于 20 年零 362 天前，其中的信息可能已发生改变或有所发展。
Metastatic pattern suggests prognosis in nasopharyngeal carcinoma
Posted: August 05, 2004
NEW YORK (Reuters Health) - The presence of isolated lung metastases in patients with nasopharyngeal carcinoma (NPC) suggests a relatively favorable prognosis, according to a report in the July 15th issue of Cancer.
"We believe that all patients with metastatic cancer, in particular nasopharyngeal cancer, belong to a heterogeneous group with very different prognoses," Dr. Edwin P. Hui from the Prince of Wales Hospital, Hong Kong told Reuters Health. Looking at patients by different metastatic sites is one method to develop a prognosis.
Dr. Hui and colleagues examined the pattern and predictive factors of distant metastases in 2915 patients with NPC without distant metastases at the time of primary radiotherapy.
Overall survival varied widely among patients with metastatic failure at different sites, the authors report. Patients with lung metastases had a significantly longer median overall survival than patients with metastases to other sites.
The baseline characteristics of the 41 patients with pure lung metastasis did not differ from those of the entire cohort, the report indicates. Their overall survival remained significantly better after adjustment for other significant prognostic factors (p = 0.0003).
"The precise predictive factor for this prognostic group cannot be identified based on the available clinical parameters," the investigators write. "We postulate that it may be associated with a unique biologic behavior of NPC in this particular group."
Distant metastases were the most common mode of failure (14.9%), the researchers note. International Union Against Cancer (UICC) N classification, UICC T classification, advanced age, and male gender were independent risk factors for distant metastases.Dr. Hui's group plans to use genomics and proteomics to examine the link between survival and individual metastatic sites. "We have been building a tissue and serum bank for this type of study."
"We would like to see if our findings would also be applicable to other cancer types," Dr. Hui added.
Posted: August 05, 2004
NEW YORK (Reuters Health) - The presence of isolated lung metastases in patients with nasopharyngeal carcinoma (NPC) suggests a relatively favorable prognosis, according to a report in the July 15th issue of Cancer.
"We believe that all patients with metastatic cancer, in particular nasopharyngeal cancer, belong to a heterogeneous group with very different prognoses," Dr. Edwin P. Hui from the Prince of Wales Hospital, Hong Kong told Reuters Health. Looking at patients by different metastatic sites is one method to develop a prognosis.
Dr. Hui and colleagues examined the pattern and predictive factors of distant metastases in 2915 patients with NPC without distant metastases at the time of primary radiotherapy.
Overall survival varied widely among patients with metastatic failure at different sites, the authors report. Patients with lung metastases had a significantly longer median overall survival than patients with metastases to other sites.
The baseline characteristics of the 41 patients with pure lung metastasis did not differ from those of the entire cohort, the report indicates. Their overall survival remained significantly better after adjustment for other significant prognostic factors (p = 0.0003).
"The precise predictive factor for this prognostic group cannot be identified based on the available clinical parameters," the investigators write. "We postulate that it may be associated with a unique biologic behavior of NPC in this particular group."
Distant metastases were the most common mode of failure (14.9%), the researchers note. International Union Against Cancer (UICC) N classification, UICC T classification, advanced age, and male gender were independent risk factors for distant metastases.Dr. Hui's group plans to use genomics and proteomics to examine the link between survival and individual metastatic sites. "We have been building a tissue and serum bank for this type of study."
"We would like to see if our findings would also be applicable to other cancer types," Dr. Hui added.
回复收藏点赞
