上消化道肿瘤治疗的新药和新策略

文题：Innovative drugs and strategies in the treatment of upper gastrointestinal tract carcinomas.
作者：Menges M, Hoehler T.
杂志全名：Onkologie
年份，卷（期）， 起止页码：2004 Feb;27(1):47-53.
英文摘要：The results of the standard therapy of upper gastrointestinal tract cancer remain unsatisfactory, mainly because still the majority of cases are diagnosed at a late stage of disease, which implicates a poor prognosis. Innovative strategies focus on neoadjuvant chemotherapy in locally advanced gastric cancer and chemo- or radiochemotherapy in advanced oesophageal cancer. Results of phase II studies published so far have been promising. There is rising evidence that adjuvant radiochemotherapy in gastric cancer may be of benefit for curatively resected patients, whereas the results of trials including a systematic lymphadenectomy have to be awaited. New substances like the taxanes or irinotecan in the palliative setting did not prove to be superior to platinum-based standard chemotherapy protocols so far.

中文摘要：上消化道肿瘤治疗的新药和新策略

上消化道肿瘤尚未形成令人满意的标准化疗方案，其主要原因是由于发现时多半已经处于晚期，预后较差。局部进展期胃癌的新辅助化疗以及进展期食管癌的化疗或放化疗是新的研究重点。即将发表的相关2期研究结果令人期待。越来越多的证据表明，对于可以手术的胃癌病人，术后放化疗是有益的，只是手术必须进行规范的淋巴结清扫。在姑息化疗中，类似紫杉醇或伊利替康等新药相对于以铂类为基础的方案并没有显示出特别优越之处。