美国医学会（编辑部述评）：孕期母亲损伤与脑性瘫痪

Editorial

November 28, 2022

Cerebral Palsy and Maternal Injury During Pregnancy

Zeyan Liew, PhD, MPH1,2; Haoran Zhuo, MPH1,2

Author Affiliations

JAMA Pediatr. Published online November 28, 2022. doi:10.1001/jamapediatrics.2022.4541

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Cerebral palsy (CP) remains the most common lifelong physical disability condition in childhood, affecting about 2 to 4 children per 1000 live births each year in high-income countries. The etiological causes for most CP cases remain unknown,1 and only a few perinatal risk factors, such as birth asphyxia, preterm delivery, and infections, have been identified.2 Ahmed and colleagues3 conducted a large medical linkage cohort study of CP that included more than 2 million mothers and children living in Ontario, Canada, and reported that maternal unintentional injury during pregnancy was associated with a higher risk for CP in the offspring (hazard ratio, 1.33; 95% CI, 1.18-1.50). The study showed that maternal injuries that were severe, such as those resulting in hospitalization or having to deliver within a week following the injuries, were more strongly associated with the offspring’s CP risk. A large study sample size allowed several subgroup analyses, including the investigation of the frequency, types, and trimesters of occurrence of the injuries.