与TGF-Beta相关的因子的信号机制 nature综述
这个帖子发布于 21 年零 278 天前，其中的信息可能已发生改变或有所发展。
由体内分泌的信号分子组成的TGF-Beta大家族含有约30种蛋白，包括骨形态发生蛋白和Activins。除调节细胞功能外，TGF-Beta蛋白还参与发育和致癌作用。它们通过II-型和I-型TGF-Beta受体及细胞内受动器（被称为Smads）来将信号传输给核子。Derynck等人对在理解与TGF-Beta相关的因子的信号机制方面所取得的最新进展做了综述，其重点是一个既涉及依赖于Smad的通道、又涉及独立于Smad的通道的复杂系统的多功能性。
Nature 425, 577 - 584 (09 October 2003); doi:10.1038/nature02006
Smad-dependent and Smad-independent pathways in TGF- family signalling
RIK DERYNCK1 AND YING E. ZHANG2
Transforming growth factor- (TGF-) proteins regulate cell function, and have key roles in development and carcinogenesis. The intracellular effectors of TGF- signalling, the Smad proteins, are activated by receptors and translocate into the nucleus, where they regulate transcription. Although this pathway is inherently simple, combinatorial interactions in the heteromeric receptor and Smad complexes, receptor-interacting and Smad-interacting proteins, and cooperation with sequence-specific transcription factors allow substantial versatility and diversification of TGF- family responses. Other signalling pathways further regulate Smad activation and function. In addition, TGF- receptors activate Smad-independent pathways that not only regulate Smad signalling, but also allow Smad-independent TGF- responses.
Nature 425, 577 - 584 (09 October 2003); doi:10.1038/nature02006
Smad-dependent and Smad-independent pathways in TGF- family signalling
RIK DERYNCK1 AND YING E. ZHANG2
Transforming growth factor- (TGF-) proteins regulate cell function, and have key roles in development and carcinogenesis. The intracellular effectors of TGF- signalling, the Smad proteins, are activated by receptors and translocate into the nucleus, where they regulate transcription. Although this pathway is inherently simple, combinatorial interactions in the heteromeric receptor and Smad complexes, receptor-interacting and Smad-interacting proteins, and cooperation with sequence-specific transcription factors allow substantial versatility and diversification of TGF- family responses. Other signalling pathways further regulate Smad activation and function. In addition, TGF- receptors activate Smad-independent pathways that not only regulate Smad signalling, but also allow Smad-independent TGF- responses.
