【讨论】细胞康复
发布于 2005-07-21 · 浏览 864 · IP 广东广东
这个帖子发布于 19 年零 320 天前，其中的信息可能已发生改变或有所发展。
康复一般用于描述动物或人的个体。最近有人将其拓展用于描述细胞过程（Korogodin et al 1997,King et al 2001），但没有明确提出细胞康复的概念。细胞有很多状态。根据细胞功能的状况可以将细胞分为健康细胞和病理细胞，健康细胞功能正常，病理细胞则功能低下。与个体的康复类似，我们将病理细胞功能恢复到正常状态的过程称之为细胞康复。
King LB, Monroe JG. 2001. Immunology - B cell receptor rehabilitation - Pausing to reflect. Science 291 (5508): 1503-1505 FEB 23 2001 （全文见附件）.
Immunologists have long been fascinated by how the immune system gets rid of immature B cells carrying antibody against self antigens before they can do any real damage. Clonal deletion (death) and clonal anergy (disability) are two mechanisms for inducing tolerance to self antigens in order to avoid autoimmunity. Recently, a third more parsimonious mechanism, receptor editing, has been described. However, it has been difficult to reconcile how cell death and receptor editing can coexist as distinct tolerance mechanisms. Even more contentious has been defining the stage in B cell development where these processes take place. Now, according to King and Monroe in their Perspective, recent work by Casellas et al. may have shed some light on these issues. Self-reactive B cells pause during their development in the bone marrow and attempt to remove the offending antibodies without destroying or inactivating the developing B cells that bear them. Those that fail to accomplish this are likely doomed to die.
Korogodin VI, Korogodina VL. 1997. Small doses and cell rehabilitation. RUSS J ECOL+ RUSSIAN JOURNAL OF ECOLOGY 28 (1): 20-24 JAN-FEB 1997. The least studied subject in biology is the action of small doses which are determined by extrapolation to low doses from the effects of considerably higher doses. Quantitative regularities for the action of radiation are considered to be the same for both high and low doses and not dependent on dose rate. In reality, this is not true. Particularly, cell rehabilitation under low irradiation rates can essentially lower the efficiency of chronic irradiation in comparison with acute irradiation. Owing to this, the values of doses with no consequences for humans under chronic irradiation can be considerably higher than those currently recognized.
我们通过总结三十多年的光生物调节作用研究提出了光生物调节作用可以作为一种细胞康复手段的假设。感兴趣的网友可以参加如下讨论
【讨论】光生物调节作用的细胞康复假说
http://www.dxy.cn/bbs/post/view?bid=116&id=3857790&sty=1&tpg=1&age=30
King LB, Monroe JG. 2001. Immunology - B cell receptor rehabilitation - Pausing to reflect. Science 291 (5508): 1503-1505 FEB 23 2001 （全文见附件）.
Immunologists have long been fascinated by how the immune system gets rid of immature B cells carrying antibody against self antigens before they can do any real damage. Clonal deletion (death) and clonal anergy (disability) are two mechanisms for inducing tolerance to self antigens in order to avoid autoimmunity. Recently, a third more parsimonious mechanism, receptor editing, has been described. However, it has been difficult to reconcile how cell death and receptor editing can coexist as distinct tolerance mechanisms. Even more contentious has been defining the stage in B cell development where these processes take place. Now, according to King and Monroe in their Perspective, recent work by Casellas et al. may have shed some light on these issues. Self-reactive B cells pause during their development in the bone marrow and attempt to remove the offending antibodies without destroying or inactivating the developing B cells that bear them. Those that fail to accomplish this are likely doomed to die.
Korogodin VI, Korogodina VL. 1997. Small doses and cell rehabilitation. RUSS J ECOL+ RUSSIAN JOURNAL OF ECOLOGY 28 (1): 20-24 JAN-FEB 1997. The least studied subject in biology is the action of small doses which are determined by extrapolation to low doses from the effects of considerably higher doses. Quantitative regularities for the action of radiation are considered to be the same for both high and low doses and not dependent on dose rate. In reality, this is not true. Particularly, cell rehabilitation under low irradiation rates can essentially lower the efficiency of chronic irradiation in comparison with acute irradiation. Owing to this, the values of doses with no consequences for humans under chronic irradiation can be considerably higher than those currently recognized.
我们通过总结三十多年的光生物调节作用研究提出了光生物调节作用可以作为一种细胞康复手段的假设。感兴趣的网友可以参加如下讨论
【讨论】光生物调节作用的细胞康复假说
http://www.dxy.cn/bbs/post/view?bid=116&id=3857790&sty=1&tpg=1&age=30
最后编辑于 2005-07-27 · 浏览 864
1 1 点赞
