The first issue of PLoS Computational Biology

http://compbiol.plosjournals.org/perlserv/?request=get-toc&issn=1553-7358&volume=1&issue=1

Message from ISCB
An Open Forum for Computational Biology e5
Michael Gribskov

Perspectives
“Antedisciplinary” Science e6
Sean R. Eddy

Research Articles
Ab Initio Prediction of Transcription Factor Targets Using Structural Knowledge e1
Tommy Kaplan, Nir Friedman, Hanah Margalit

What Makes Ribosome-Mediated Transcriptional Attenuation Sensitive to Amino Acid Limitation? e2
Johan Elf, Måns Ehrenberg

Predicting Functional Gene Links from Phylogenetic-Statistical Analyses of Whole Genomes e3
Daniel Barker, Mark Pagel

Combinatorial Pattern Discovery Approach for the Folding Trajectory Analysis of a β-Hairpin e8
Laxmi Parida, Ruhong Zhou

Susceptibility to Superhelically Driven DNA Duplex Destabilization: A Highly Conserved Property of Yeast Replication Origins e7
Prashanth Ak, Craig J. Benham

Improving the Precision of the Structure–Function Relationship by Considering Phylogenetic Context e9
Boris E. Shakhnovich

microRNA Target Predictions across Seven Drosophila Species and Comparison to Mammalian Targets e13
Dominic Grün, Yi-Lu Wang, David Langenberger, Kristin C. Gunsalus, Nikolaus Rajewsky

Extraction of Transcript Diversity from Scientific Literature e10
Parantu K. Shah, Lars J. Jensen, Stéphanie Boué, Peer Bork

A Phenomenological Theory of Spatially Structured Local Synaptic Connectivity e11
Bagrat Amirikian

The Genomic Pattern of tDNA Operon Expression in E. coli e12
David H. Ardell, Leif A. Kirsebom