PaperWeekly----第131期（18 Jan 2018）

PaperWeekly----第131期（18 Jan 2018）

周博通

这里我们精选了这一周发表的优秀论文与您共享，如果您对其中某篇文献内容有自己的想法，或者您知道研究背后的故事，又或者您对疼痛研究有自己的视角和见解，欢迎您为我们撰写相关文章， 十分感谢！

本周推送文章：

目录：

1.Male-Specific Conditioned Pain Hypersensitivity in Mice and Humans.

摘要：

1.Male-Specific Conditioned Pain Hypersensitivity in Mice and Humans.

雄性小鼠和男性的条件位置性痛觉过敏

Martin LJ, Acland EL, Cho C, Gandhi W, Chen D, Corley E, Kadoura B, Levy T, Mirali S, Tohyama S, Khan S, MacIntyre LC, Carlson EN, Schweinhardt P, Mogil JS.

Curr Biol. 2019 Jan 3.

PMID: 30639112

Abstract

Pain memories are hypothesized to be critically involved in the transition of pain from an acute to a chronic state. To help elucidate the underlying neurobiological mechanisms of pain memory, we developed novel paradigms to study context-dependent pain hypersensitivity in mouse and human subjects, respectively. We find that both mice and people become hypersensitive to acute, thermal nociception when tested in an environment previously associated with an aversive tonic pain experience. This sensitization persisted for at least 24 hr and was only present in males of both species. In mice, context-dependent pain hypersensitivity was abolished by castrating male mice, pharmacological blockade of the hypothalamic-pituitary-adrenal axis, or intracerebral or intrathecal injections of zeta inhibitory peptide (ZIP) known to block atypical protein kinase C (including the protein kinase Mζ isoform). In humans, men, but not women, self-reported higher levels of stress when tested in a room previously associated with tonic pain. These models provide a new, completely translatable means for studying the relationship between memory, pain, and stress.

文献地址: https://linkinghub.elsevier.com/retrieve/pii/S0960-9822(18)31496-9

Jeffrey group总是出一些标新的paper