【进展】导管相关尿路感染的预防性抗生素
这个帖子发布于 12 年零 311 天前，其中的信息可能已发生改变或有所发展。
本研究旨在评估短中期导尿术时使用预防性抗生素左氧氟沙星（LVFX）的用处。研究将评估和确认术后（3-14天）患者中短期留置导尿时，左氧氟沙星250mg口服在预防导管相关尿路感染的有效性以及需求。
本研究是一个具有平行组、多中心、随机和在三组中使用安慰剂对照的III期试验。研究中，A、B组为双盲组，C组为单盲组。研究共招募120位患者，每组40人。研究显示两种类型的结果，其中一个主要基于首要有效性变量，另一个基于次要有效性变量。与安慰剂组相比，LVFX治疗组在菌尿和脓尿测试阴性的趋势更显著，基本上可与环丙沙星治疗的患者组相媲美。
本研究表明，左氧氟沙星可能是有用于阻止中短期CAUTI。
Petronella P, Scorzelli M, Fiore A, Corbisiero MC, Agresti E, Esposito S, Freda F. Antibiotic prophylaxis in catheter-associated urinary infections. New Microbiol. 2012 Apr;35(2):191-8. Epub 2012 Mar 31.
Abstract
This study aimed to assess the usefulness of antibiotic prophylaxis with Levofloxacin (LVFX) in short and mediumterm catheterisations. This study was developed to evaluate and confirm the effectiveness and need for prophylaxis in preventing catheter-associated UTIs, using LVFX at a dose of 250 mg administered orally to patients who had been subjected to short and medium-term urinary bladder catheterisation following surgery (3-14 days). The study was designed as a phase III study with parallel groups, multicentre, randomised, controlled with a placebo in three groups. The study was double-blind in treatment groups A and B and single-blind in group C. The study involved the recruitment of 120 patients, 40 for each treatment group. We show two types of results, one based on primary effectiveness variables and the other on the secondary effectiveness variables. The group treated with LVFX displayed a greater tendency toward the negativisation of bacteriuria and pyuria tests than that recorded for the placebo group, and was essentially comparable to that recorded for the group of patients treated with Ciprofloxacin. We can thus affirm that LVFX may be useful for preventing short and medium-term CAUTIs.
本研究是一个具有平行组、多中心、随机和在三组中使用安慰剂对照的III期试验。研究中，A、B组为双盲组，C组为单盲组。研究共招募120位患者，每组40人。研究显示两种类型的结果，其中一个主要基于首要有效性变量，另一个基于次要有效性变量。与安慰剂组相比，LVFX治疗组在菌尿和脓尿测试阴性的趋势更显著，基本上可与环丙沙星治疗的患者组相媲美。
本研究表明，左氧氟沙星可能是有用于阻止中短期CAUTI。
Petronella P, Scorzelli M, Fiore A, Corbisiero MC, Agresti E, Esposito S, Freda F. Antibiotic prophylaxis in catheter-associated urinary infections. New Microbiol. 2012 Apr;35(2):191-8. Epub 2012 Mar 31.
Abstract
This study aimed to assess the usefulness of antibiotic prophylaxis with Levofloxacin (LVFX) in short and mediumterm catheterisations. This study was developed to evaluate and confirm the effectiveness and need for prophylaxis in preventing catheter-associated UTIs, using LVFX at a dose of 250 mg administered orally to patients who had been subjected to short and medium-term urinary bladder catheterisation following surgery (3-14 days). The study was designed as a phase III study with parallel groups, multicentre, randomised, controlled with a placebo in three groups. The study was double-blind in treatment groups A and B and single-blind in group C. The study involved the recruitment of 120 patients, 40 for each treatment group. We show two types of results, one based on primary effectiveness variables and the other on the secondary effectiveness variables. The group treated with LVFX displayed a greater tendency toward the negativisation of bacteriuria and pyuria tests than that recorded for the placebo group, and was essentially comparable to that recorded for the group of patients treated with Ciprofloxacin. We can thus affirm that LVFX may be useful for preventing short and medium-term CAUTIs.
回复2 点赞
