【翻译】信号转导版国际最新文献学习交流平台暨大型文献翻译活动：第1期！欢迎大家踊跃参加，加分从优！
推荐这个帖子发布于 15 年零 283 天前，其中的信息可能已发生改变或有所发展。
受其他版块以往活动的启迪，为鼓励战友们多学习国外文献和提高英语阅读能力，及时跟踪、学习细胞信号转导领域相关研究的最新进展，特举办此次翻译活动。
活动方法：
1.请在此帖处跟帖，不要另开新帖。
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2.请严格按照如下格式发帖：（按照Pubmed的格式）举例如下(注意要将Pubmed的英文摘要全部贴上，以便于大家对照阅读)：
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研究内容：NF-κB signaling（涉及的信号通路名称）
杂志全名及年卷期：Int J Cancer. 2009 Nov 1;125(9):2187-97. IF（2008）=4.734
文题： Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model.
作者：Kunnumakkara AB, Diagaradjane P, Anand P, Kuzhuvelil HB, Deorukhkar A, Gelovani J, Guha S, Krishnan S, Aggarwal BB.
英文摘要：Because of the poor prognosis and the development of resistance against chemotherapeutic drugs, the current treatment for advanced metastatic colorectal cancer (CRC) is ineffective. Whether curcumin (a component of turmeric) can potentiate the effect of capecitabine against growth and metastasis of CRC was investigated. The effect of curcumin on proliferation of CRC cell lines was examined by mitochondrial dye-uptake assay, apoptosis by esterase staining, nuclear factor-kappaB (NF-kappaB) by electrophoretic mobility shift assay and gene expression by Western blot analysis. The effect of curcumin on the growth and metastasis of CRC was also examined in orthotopically implanted tumors in nude mice. In vitro, curcumin inhibited the proliferation of human CRC cell lines, potentiated capecitabine-induced apoptosis, inhibited NF-kappaB activation and suppressed NF-kappaB-regulated gene products. In nude mice, the combination of curcumin and capecitabine was found to be more effective than either agent alone in reducing tumor volume (p = 0.001 vs. control; p = 0.031 vs. capecitabine alone), Ki-67 proliferation index (p = 0.001 vs. control) and microvessel density marker CD31. The combination treatment was also highly effective in suppressing ascites and distant metastasis to the liver, intestines, lungs, rectum and spleen. This effect was accompanied by suppressed expression of activated NF-kappaB and NF-kappaB-regulated gene products (cyclin D1,c-myc, bcl-2, bcl-xL, cIAP-1, COX-2, ICAM-1, MMP-9, CXCR4 and VEGF). Overall, our results suggest that curcumin sensitizes CRC to the antitumor and antimetastatic effects of capecitabine by suppressing NF-kappaB cell signaling pathway.
PMID： 19623659 [PubMed - indexed for MEDLINE]
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中文翻译：
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题目：。。。。。
摘要：。。。。。
>
点评：（内容为结合自己课题、研究体会和其他文献复习后对该文章实验设计和研究结果的意义等的评价，严禁抄袭！）
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3.只要求翻译题目和摘要（重在交流，因此可以适当意译）并作出必要的点评，不要求提供全文或相关图片。
>
4.可以对其他战友翻译及点评内容做出自己的评价，发表自己的见解，只要有理有据，同样可以得到加分鼓励。
>
5.选题必须是您发表帖子时3个月之内（包括当月）的杂志文章。杂志的影响因子（2008）应在2.0以上。如下杂志供参考：
> Cell
> Nature
> Science
> Proc Natl Acad Sci U S A
> Stem Cells
> Cancer
> Cancer cell
> Cancer research
> J Biol Chem
> Cell Signal
> Int J Cancer
> ....
6.发帖前请务必先搜索，避免重复！
>
奖励办法：
> 1、对严格按照要求发帖者予以积分奖励。视翻译及点评水平和文章的价值，加1－3分。
> 2、对于优秀的文献及翻译，请大家不要吝惜手中的投票权！
>
说明：
本版版主对该活动有最终解释权，同时该活动也将会不断完善，长期坚持下去；对于关注度高、意义深远的文献（按得票数评定）还会邀请资深战友解读或采用专题讨论的形式供大家学习交流。欢迎大家踊跃参与！
活动方法：
1.请在此帖处跟帖，不要另开新帖。
>
2.请严格按照如下格式发帖：（按照Pubmed的格式）举例如下(注意要将Pubmed的英文摘要全部贴上，以便于大家对照阅读)：
>
研究内容：NF-κB signaling（涉及的信号通路名称）
杂志全名及年卷期：Int J Cancer. 2009 Nov 1;125(9):2187-97. IF（2008）=4.734
文题： Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model.
作者：Kunnumakkara AB, Diagaradjane P, Anand P, Kuzhuvelil HB, Deorukhkar A, Gelovani J, Guha S, Krishnan S, Aggarwal BB.
英文摘要：Because of the poor prognosis and the development of resistance against chemotherapeutic drugs, the current treatment for advanced metastatic colorectal cancer (CRC) is ineffective. Whether curcumin (a component of turmeric) can potentiate the effect of capecitabine against growth and metastasis of CRC was investigated. The effect of curcumin on proliferation of CRC cell lines was examined by mitochondrial dye-uptake assay, apoptosis by esterase staining, nuclear factor-kappaB (NF-kappaB) by electrophoretic mobility shift assay and gene expression by Western blot analysis. The effect of curcumin on the growth and metastasis of CRC was also examined in orthotopically implanted tumors in nude mice. In vitro, curcumin inhibited the proliferation of human CRC cell lines, potentiated capecitabine-induced apoptosis, inhibited NF-kappaB activation and suppressed NF-kappaB-regulated gene products. In nude mice, the combination of curcumin and capecitabine was found to be more effective than either agent alone in reducing tumor volume (p = 0.001 vs. control; p = 0.031 vs. capecitabine alone), Ki-67 proliferation index (p = 0.001 vs. control) and microvessel density marker CD31. The combination treatment was also highly effective in suppressing ascites and distant metastasis to the liver, intestines, lungs, rectum and spleen. This effect was accompanied by suppressed expression of activated NF-kappaB and NF-kappaB-regulated gene products (cyclin D1,c-myc, bcl-2, bcl-xL, cIAP-1, COX-2, ICAM-1, MMP-9, CXCR4 and VEGF). Overall, our results suggest that curcumin sensitizes CRC to the antitumor and antimetastatic effects of capecitabine by suppressing NF-kappaB cell signaling pathway.
PMID： 19623659 [PubMed - indexed for MEDLINE]
>
中文翻译：
>
题目：。。。。。
摘要：。。。。。
>
点评：（内容为结合自己课题、研究体会和其他文献复习后对该文章实验设计和研究结果的意义等的评价，严禁抄袭！）
>
3.只要求翻译题目和摘要（重在交流，因此可以适当意译）并作出必要的点评，不要求提供全文或相关图片。
>
4.可以对其他战友翻译及点评内容做出自己的评价，发表自己的见解，只要有理有据，同样可以得到加分鼓励。
>
5.选题必须是您发表帖子时3个月之内（包括当月）的杂志文章。杂志的影响因子（2008）应在2.0以上。如下杂志供参考：
> Cell
> Nature
> Science
> Proc Natl Acad Sci U S A
> Stem Cells
> Cancer
> Cancer cell
> Cancer research
> J Biol Chem
> Cell Signal
> Int J Cancer
> ....
6.发帖前请务必先搜索，避免重复！
>
奖励办法：
> 1、对严格按照要求发帖者予以积分奖励。视翻译及点评水平和文章的价值，加1－3分。
> 2、对于优秀的文献及翻译，请大家不要吝惜手中的投票权！
>
说明：
本版版主对该活动有最终解释权，同时该活动也将会不断完善，长期坚持下去；对于关注度高、意义深远的文献（按得票数评定）还会邀请资深战友解读或采用专题讨论的形式供大家学习交流。欢迎大家踊跃参与！
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