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【求助】翻译:Current concepts in the pathophysiology of testicular undescent

发布于 2005-12-06 · 浏览 942 · IP 广西广西
这个帖子发布于 19 年零 183 天前,其中的信息可能已发生改变或有所发展。
作为一名基层医师,要了解当前国际进展相当困难,因为英语奇臭,所以,期盼大虾们帮助翻译:
Current concepts in the pathophysiology of testicular undescent.

At present, we believe that descent of the testes within the human is a complex event mediated by both hormonal and mechanical factors. We hypothesize that descent of the testes occurs as a result of the secretion of an androgen-independent factor from a normal testis (descendin). This paracrine factor is responsible for the rapid proliferation (outgrowth) of the ipsilateral gubernaculum. The development of the gubernaculum results in creating a dilated inguinal canal, the width of which matches the testicular width. Descent of the testes through the inguinal canal is an interplay between abdominal pressure, a patent processus vaginalis, and androgen-induced gubernacular regression. We hypothesize that androgens (under control of an intact hypothalamic pituitary axis) alter the viscoelastic properties of the gubernaculum, reducing the turgidity of the gubernaculum and allowing intra-abdominal pressure to push the testis into the scrotum. Cryptorchidism can therefore result when any one or more of the involved factors malfunction.


最后编辑于 2005-12-07 · 浏览 942

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