鼻咽癌三期临床试验预结果
这个帖子发布于 19 年零 258 天前，其中的信息可能已发生改变或有所发展。
鼻咽癌号称广东瘤，但长期以来我国的临床研究很少在国外主流医学杂志发表，这次终于有所收获，可喜可贺。以下是NCI专家Norman Coleman对这个试验的评价：
This study was very well done.
Although the 1998 Intergroup 0099 trial changed the standard practice in this country, it was so effective they stopped it early. Therefore, this confirmatory trial adds important additional information as to the efficacy of chemoradiotherapy as well as the drugs that might be used.
Both of the trials used platinum-based chemotherapy. This trial demonstrates that oxaliplatin is an excellent choice to complement radiation, as is cisplatin from the initial Intergroup Trial.
We know chemoradiotherapy with a platinum drug improves cancer control locally. The improvement in local control does not always result in an improvement in metastasis-free survival and overall survival. These data suggest that persistent tumor leads to additional metastases, so that improving local control has multiple benefits.”
Longer follow-up will be important, of course
There is no reason to believe results in these Chinese subjects would not reflect on the experience of patients in the United States
This study was very well done.
Although the 1998 Intergroup 0099 trial changed the standard practice in this country, it was so effective they stopped it early. Therefore, this confirmatory trial adds important additional information as to the efficacy of chemoradiotherapy as well as the drugs that might be used.
Both of the trials used platinum-based chemotherapy. This trial demonstrates that oxaliplatin is an excellent choice to complement radiation, as is cisplatin from the initial Intergroup Trial.
We know chemoradiotherapy with a platinum drug improves cancer control locally. The improvement in local control does not always result in an improvement in metastasis-free survival and overall survival. These data suggest that persistent tumor leads to additional metastases, so that improving local control has multiple benefits.”
Longer follow-up will be important, of course
There is no reason to believe results in these Chinese subjects would not reflect on the experience of patients in the United States
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