肝癌基因治疗的回顾----到临床究竟多远?
肝细胞癌,是一种全世界最流行的原发性肝癌的组织形式。这种病理(治疗)仍需要新的治疗方案的发展。 关注于介导癌细胞的免疫反应辅助细胞的基因操作,或者直接向肿瘤细胞中导入(治疗,自杀)基因引起癌细胞的自杀基因治疗测略,在这方面研究已经约有10年多的历史了。本文就次给出了全面而详尽的说明,如果有兴趣的话可以看看!Hepatocellular carcinoma (HCC), the most prevalent histological form of primary liver cancer is one of the most frequent cancer worldwide. This pathology still requires the development of new therapeutical approaches. Gene therapy strategies focusing on the genetic manipulation of accessory cells involved in the immune reaction against cancer cells, or on the direct transduction of tumor cells with transgenes able to ‘‘suicide’’ cancer cells have been largely developed for more than ten years.
Cancer Gene Therapy (2003) 10, 649–660.