求大神帮忙翻译 谢谢！

During the ATRA induction treatment, morphologically recognizable changes in most promyelocytes of patients with PML-RARA could be observed. The nucleus became larger, and fewer prominent primary granules along with the development of secondary granules were observed in the cytoplasm with condensation and segmentation of nuclei. An elevated population of metamyelocytes was evident, with indented or horseshoe-shaped nuclei and reduced  nuclear/cytoplasmic ratio, although the  ucleoplasm remained immature. We designated these promyelocytes with morphological changes as “ATRA-induced cells”。

请大神帮忙翻译一下这一段话，这个描述的形态改变我不太理解，早有粒细胞被诱导后应该是变成熟了，那么他的细胞核为什么会变大呢？