【摘要翻译】凝血酸(TXA)在经尿道前列腺切除术中控制原发出血的应用
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UROLOGY 64: 955–958, 2004.
TRANEXAMIC ACID IN CONTROL OF PRIMARY HEMORRHAGE DURING TRANSURETHRAL PROSTATECTOMY
ANTTI RANNIKKO, ANSSI PÉTAS, AND KIMMO TAARI
From the Department of Urology, Helsinki University Central
Hospital, Helsinki, Finland
ABSTRACT
Objectives. To determine whether short-term treatment of patients about to undergo transurethral resection of the prostate (TURP) with tranexamic acid (TXA) would be beneficial in reducing the associated blood loss.
Methods. A prospective and randomized trial was conducted with 136 men requiring TURP for obstructive urinary symptoms. The treatment group received 2 g TXA three times daily on the day of, and first day after,the operation.
Results. Short-term TXA treatment significantly reduced the operative blood loss associated with TURP (128 mL versus 250 mL, P = 0.018), and this difference was not a result of the amount of tissue resected between the two groups (16 g versus 16 g, P = 0.415). In addition, TXA treatment reduced the amount of blood loss per gram of resected tissue (8 mL/g versus 13 mL/g, P = 0.020).
Furthermore, the volume of irrigating fluid required (15 L versus 18 L, P = 0.004) and operating time (36 minutes versus 48 minutes, P = 0.001) were also reduced. However, TXA treatment did not influence the number of patients requiring a blood transfusion.
Six patients in the treatment group (7.2%) and five in the control group (6.8%) required a transfusion (P = 0.709). Moreover, TXA treatment did not affect the duration of catheterization (1 day
versus 1 day, P = 0.342) or hospitalization (3 days versus 3 days, P = 0.218).
Conclusions. Short-term TXA treatment is effective in reducing the operative blood loss associated with TURP.
摘要
目的:明确在将要进行经尿道前列腺切除术（TURP）的病人中短期使用凝血酸（TXA）是否具有减少术中出血的作用。
方法：在136 例有梗阻性排尿症状需要进行TURP的患者中进行前瞻性和随机研究。处理组患者在手术当天和术后第一天给予TXA 2g 3次/日。
结果： 短期使用TXA可以明显减少TURP伴随出血（128ml Vs 250ml, P=0.018），并且这种差异不是由于两组病人组织切除量的不同造成的(16 g Vs 16 g, P = 0.415)。另外，TXA可减少每克切除组织的失血量(8 mL/g Vs 13 mL/g, P = 0.020)。而且，灌洗液的用量(15 L Vs 18 L, P = 0.004)和手术时间(36 min Vs 48 min, P = 0.001)都相应减少。然而，TXA对需要输血的病人数量并没有影响。处理组的6例患者（7.2%）和对照组的5例患者(6.8%)都进行了输血(P = 0.709)。还有，TXA对术后置管时间(1 day Vs 1 day, P = 0.342)和住院时间(3 days Vs 3 days, P = 0.218)也没有影响。
结论：短期使用TXA可以有效减少TURP术中出血。
TRANEXAMIC ACID IN CONTROL OF PRIMARY HEMORRHAGE DURING TRANSURETHRAL PROSTATECTOMY
ANTTI RANNIKKO, ANSSI PÉTAS, AND KIMMO TAARI
From the Department of Urology, Helsinki University Central
Hospital, Helsinki, Finland
ABSTRACT
Objectives. To determine whether short-term treatment of patients about to undergo transurethral resection of the prostate (TURP) with tranexamic acid (TXA) would be beneficial in reducing the associated blood loss.
Methods. A prospective and randomized trial was conducted with 136 men requiring TURP for obstructive urinary symptoms. The treatment group received 2 g TXA three times daily on the day of, and first day after,the operation.
Results. Short-term TXA treatment significantly reduced the operative blood loss associated with TURP (128 mL versus 250 mL, P = 0.018), and this difference was not a result of the amount of tissue resected between the two groups (16 g versus 16 g, P = 0.415). In addition, TXA treatment reduced the amount of blood loss per gram of resected tissue (8 mL/g versus 13 mL/g, P = 0.020).
Furthermore, the volume of irrigating fluid required (15 L versus 18 L, P = 0.004) and operating time (36 minutes versus 48 minutes, P = 0.001) were also reduced. However, TXA treatment did not influence the number of patients requiring a blood transfusion.
Six patients in the treatment group (7.2%) and five in the control group (6.8%) required a transfusion (P = 0.709). Moreover, TXA treatment did not affect the duration of catheterization (1 day
versus 1 day, P = 0.342) or hospitalization (3 days versus 3 days, P = 0.218).
Conclusions. Short-term TXA treatment is effective in reducing the operative blood loss associated with TURP.
摘要
目的:明确在将要进行经尿道前列腺切除术（TURP）的病人中短期使用凝血酸（TXA）是否具有减少术中出血的作用。
方法：在136 例有梗阻性排尿症状需要进行TURP的患者中进行前瞻性和随机研究。处理组患者在手术当天和术后第一天给予TXA 2g 3次/日。
结果： 短期使用TXA可以明显减少TURP伴随出血（128ml Vs 250ml, P=0.018），并且这种差异不是由于两组病人组织切除量的不同造成的(16 g Vs 16 g, P = 0.415)。另外，TXA可减少每克切除组织的失血量(8 mL/g Vs 13 mL/g, P = 0.020)。而且，灌洗液的用量(15 L Vs 18 L, P = 0.004)和手术时间(36 min Vs 48 min, P = 0.001)都相应减少。然而，TXA对需要输血的病人数量并没有影响。处理组的6例患者（7.2%）和对照组的5例患者(6.8%)都进行了输血(P = 0.709)。还有，TXA对术后置管时间(1 day Vs 1 day, P = 0.342)和住院时间(3 days Vs 3 days, P = 0.218)也没有影响。
结论：短期使用TXA可以有效减少TURP术中出血。
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