【摘要翻译】前列腺癌的基础研究

[文题]Basic science aspects of prostate cancer
前列腺癌的基础研究
[来源]J seminars in CANCER BIOLOGY
[年、卷、期、页]Vol 8, 1997: pp 21–27
[作者]Trevor J. Dorkin and David E. Neal
[原文摘要]
Prostate cancer carries significant morbidity and mortality, but its outcome is difficult to predict in the individual. Androgen ablation delays progression in men, but hormone resistance soon develops and much basic science research has focused on how prostate cancer ‘escapes’ hormonal control.Stem cell models of prostate development and homeostasis have been proposed, but have not yet been fully characterized. Some androgen regulated signalling pathways and abnormalities that affect them have been defined recently. It is apparent that locally produced growth factors, often regulated by androgens, exert an effect both physiologically and pathologically and these too will be
discussed.
Key words: androgen / androgen receptor / growth
factors / prostate cancer / stem cell
©1997 Academic Press Ltd

[中文摘要]
前列腺癌具有显著的发病率和死亡率，但是很难去预见去它的预后。去雄激素治疗延缓了它的进展，但是治疗后不久将产生激素耐药，许多基础科学的研究集中在前列腺癌是怎样逃逸激素控制的。前列腺干细胞模型和内环境的稳定性的因素已经被提出来了，但是我们仍然还没有了解全部。一些雄激素调整信号路径和异常将影响它们被正确的定义。很明显，雄激素经常调整局部产生的生长因子，在生理和病理两方面起着作用，这些将在下面被讨论。
关键词:
雄激素/雄激素受体/生长因子/前列腺癌/干细胞