文献翻译——【目录认领贴】——Spine文献翻译系列报道（May15，2007）

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c、
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May 15, 2007, Volume 32, Issue 11
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Randomized Trial
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1、
1155 Results of the Prospective, Randomized, Multicenter Food and Drug Administration Investigational Device Exemption Study of the ProDisc(R)-L Total Disc Replacement Versus Circumferential Fusion for the Treatment of 1-Level Degenerative Disc Disease.
Jack Zigler, MD; Rick Delamarter, MD; Jeffrey M. Spivak, MD; Raymond J. Linovitz, MD, FACS; Guy O. Danielson III, MD; Thomas T. Haider, MD; Frank Cammisa, MD; Jim Zuchermann, MD; Richard Balderston, MD; Scott Kitchel, MD; Kevin Foley, MD; Robert Watkins, MD; David Bradford, MD; James Yue, MD; Hansen Yuan, MD; Harry Herkowitz, MD; Doug Geiger, MD; John Bendo, MD; Timothy Peppers, MD; Barton Sachs, MD; Federico Girardi, MD; Michael Kropf, MD; Jeff Goldstein, MD
A prospective, randomized, multicenter, Food and Drug Administration-regulated Investigational Device Exemption clinical trial was conducted comparing ProDisc®-L total disc replacement (Synthes Spine, West Chester, PA) to circumferential fusion. Two hundred eighty-six patients were treated and followed to 24 months. ProDisc®-L was shown to be safe and efficacious, and superior to circumferential fusion by multiple clinical criteria.
http://www.spinejournal.com/pt/re/spine/abstract.00007632-200705150-00002.htm



by smallcatl

Basic Science
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2、
1164 Brain-Derived Neurotrophic Factor Gene Transfer With Adeno-Associated Viral and Lentiviral Vectors Prevents Rubrospinal Neuronal Atrophy and Stimulates Regeneration-Associated Gene Expression After Acute Cervical Spinal Cord Injury.
Brian K. Kwon, MD, PhD, FRCSC; Jie Liu, MD; Clarrie Lam, BSc; Ward Plunet, BSc; Loren W. Oschipok, BSc; William Hauswirth, PhD; Adriana Di Polo, PhD; Armin Blesch, PhD; Wolfram Tetzlaff, MD, PhD
After acute cervical spinal cord injury, gene transfer of brain-derived neurotrophic factor (BDNF) using adeno-associated and lentiviral vectors was successful at promoting a regenerative response in rubrospinal neurons, with significantly less parenchymal damage than previously observed when infusing the BDNF protein.
http://www.spinejournal.com/pt/re/spine/abstract.00007632-200705150-00004.htm



by flyingzhao

3、
1174 The In Vivo Biological Effects of Intradiscal Recombinant Human Bone Morphogenetic Protein-2 on the Injured Intervertebral Disc: An Animal Experiment.
Kuo-Yuan Huang, MD; Jing-Jou Yan, MD; Chin-Chiang Hsieh, MD; Ming-Shi Chang, PhD; Ruey-Mo Lin, MD
Recombinant human bone morphogenetic protein-2 can promote hypervascularity and fibroblast proliferation in the intervertebral disc after an anular tear in the rabbit model. Recombinant human bone morphogenetic protein-2 might be associated with the injury response after disc injury.
http://www.spinejournal.com/pt/re/spine/abstract.00007632-200705150-00005.htm



by flyingzhao

4、
1181 Microarray Analysis of Laser Capture Microdissected-Anulus Cells From the Human Intervertebral Disc.
Helen E. Gruber, PhD; Jean-Luc Mougeot, PhD; Gretchen Hoelscher, MS; Jane A. Ingram, BS; Edward N. Hanley Jr, MD
During disc degeneration, cell numbers decrease, making gene expression studies challenging. Laser capture microdissection was used to harvest cells from sections of Grades I/II, III, and IV discs. A total of 47 genes were significantly differentially expressed between the 3 groups (P < 0.001), including those involving cell senescence, low cell division rates, and hypoxia-related genes.
http://www.spinejournal.com/pt/re/spine/abstract.00007632-200705150-00006.htm



by kickingnliving

5、
1188 Nucleus Pulposus Cellular Longevity by Telomerase Gene Therapy.
Sylvia A. Chung, MSc (Hon); Ai Qun Wei, MD; David E. Connor, BMedSc, Hon; Graham C. Webb, PhD; Timothy Molloy, PhD; Marina Pajic, MSc (Hon); Ashish D. Diwan, MD, PhD
Telomerase nonviral gene therapy of ovine nucleus pulposus cultures enabled the extension of cellular lifespan and the prolonged maintenance of extracellular matrix production. Karyotypic instability was detected, but no loss of contact inhibition, mitogen dependency, or G1-cell cycle checkpoint control was evident.
http://www.spinejournal.com/pt/re/spine/abstract.00007632-200705150-00007.htm



by kickingnliving

6、
1197 Restoration of Disc Height Loss by Recombinant Human Osteogenic Protein-1 Injection Into Intervertebral Discs Undergoing Degeneration Induced by an Intradiscal Injection of Chondroitinase ABC.
Yoshiyuki Imai, MD, PhD; Masahiko Okuma, MD, PhD; Howard S. An, MD; Koichi Nakagawa, MD, PhD; Michiaki Yamada, MD, PhD; Carol Muehleman, PhD; Eugene Thonar, PhD; Koichi Masuda, MD
Recombinant human osteogenic protein-1 was effective in reversing loss of disc height in rabbits presenting with disc degeneration following chemonucleolysis with chondroitinase ABC. These results suggest that recombinant human osteogenic protein-1 should be a consideration in the treatment of patients who exhibit disc height loss following previous chemonucleolysis.
http://www.spinejournal.com/pt/re/spine/abstract.00007632-200705150-00008.htm



by yanyubaihe

7、
1206 rhBMP-2 (ACS and CRM Formulations) Overcomes Pseudarthrosis in a New Zealand White Rabbit Posterolateral Fusion Model.
James P. Lawrence, MD; Walid Waked, MD; Thomas J. Gillon, MD; Andrew P. White, MD; Christopher R. Spock, BS; Debdut Biswas, BA; Patricia Rosenberger, PhD; Nancy Troiano, MS; Todd J. Albert, MD; Jonathan N. Grauer, MD
A New Zealand white rabbit model of pseudarthrosis repair was used. No graft, autograft, or rhBMP-2 with 1 of 2 formulations (absorbable collagen sponge or compression resistant matrix) was evaluated. Attempted pseudarthrosis repairs were successful in 6% no graft rabbits, 29% autograft rabbits, and 100% rhBMP-2 rabbits (with either carrier).
http://www.spinejournal.com/pt/re/spine/abstract.00007632-200705150-00009.htm



by yanyubaihe

Biomechanics
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8、
1214 The Load-Sharing Classification of Thoracolumbar Fractures: An In Vitro Biomechanical Validation.
Xiang-Yang Wang, MD, PhD; Li-Yang Dai, MD, PhD; Hua-Zi Xu, MD; Yong-Long Chi, MD
This study was designed to validate the load-sharing classification of thoracolumbar fractures in an in vitro biomechanical model. The results showed that the load-sharing scores were significantly correlated with the motion parameters. This study confirms that assessing the load-sharing score should be helpful in evaluating the acute instability of thoracolumbar fractures.
http://www.spinejournal.com/pt/re/spine/abstract.00007632-200705150-00010.htm



by perfectly007

9、
1220 Biomechanical Comparison of Instrumented and Uninstrumented Multilevel Cervical Discectomy Versus Corpectomy.
Robert M. Galler, DO; Seref Dogan, MD; Mary S. Fifield, BSE; Hakan Bozkus, MD; Robert H. Chamberlain, MS; Volker K. H. Sonntag, MD; Neil R. Crawford, PhD
Spinal stability after multilevel corpectomy or discectomy was compared after bone graft insertion, after anterior plating, and after combined anterior and posterior instrumentation. There was little difference in stability among the techniques. An anterior plate effectively stabilized both types of decompression. Adding posterior instrumentation further reduced motion significantly.
http://www.spinejournal.com/pt/re/spine/abstract.00007632-200705150-00011.htm



by hotstone

Deformity
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10、
1227 Natural History of Progressive Adult Scoliosis.
Catherine Marty-Poumarat, MD; Luciana Scattin, MD; Michèle Marpeau, MD; Christian Garreau de Loubresse, MD; Philippe Aegerter, MD, PhD
The originality of this study is the progression diagram. It demonstrated the linearity of progression of the Cobb angle over time in progressive adult scoliosis. The diagrams visualized 2 main types of progression, and the authors compared them. Menopause constitutes a period of deterioration.
http://www.spinejournal.com/pt/re/spine/abstract.00007632-200705150-00012.htm



by carlacj

Diagnostics
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11、
1236 Erector Spinae Muscle Changes on Magnetic Resonance Imaging Following Lumbar Surgery Through a Posterior Approach.
Olivier Gille, MD, PhD; Erwan Jolivet, PhD; Vincent Dousset, MD, PhD; Cécile Degrise, MD; Ibrahim Obeid, MD; Jean-Marc Vital, MD; Wafa Skalli, PhD
We used an MRI technique for evaluating erector spinae following lumbar surgery. Only slight postoperative changes were observed in the contractile component cross-sectional area of the muscles proximal to the arthrodesis, while the area was reduced by 27% distal to the procedure. Curare showed no efficacy in preventing muscle damage.
http://www.spinejournal.com/pt/re/spine/abstract.00007632-200705150-00014.htm



by smallcatl

12、
1242 Three-Dimensional Lumbar Spine Postures Measured by Magnetic Resonance Imaging Reconstruction.
Sara C. Cargill, Beng (Hons); Mark Pearcy, BSc, PhD, FIEAust, CPEng (Biomed); Mark Darrell Barry, MappSci (Computing)
A novel method of accurately determining bone position in vivo using magnetic resonance imaging. A process incorporating positional and conventional magnetic resonance imaging was used to measure the positions of the lumbar spine and pelvis. Results indicate good intrameasurer reliability. Data collected are 3-dimensional, and represent the anatomy and movement of a specific individual.
http://www.spinejournal.com/pt/re/spine/abstract.00007632-200705150-00015.htm



by carlacj

Health Services Research
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13、
1249 Cervical Transforaminal Epidural Steroid Injections: More Dangerous Than We Think?
Graham C. Scanlon, MD; Tobias Moeller-Bertram, MD; Shawn M. Romanowsky, BS; Mark S. Wallace, MD
To characterize neurologic complications following cervical transforaminal epidural steroid injections, a large cohort of pain physicians was surveyed. In all, 78 complications were reported, including 16 brain infarcts, 12 spinal cord infarcts, and 2 combined brain/cord infarcts. There were 13 fatalities, and a strong association was found with particulate corticosteroids.
http://www.spinejournal.com/pt/re/spine/abstract.00007632-200705150-00016.htm



by myamulet

Biomechanics
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14、
E330 Biomechanical Testing Simulation of a Cadaver Spine Specimen: Development and Evaluation Study.
Hyung Soo Ahn, MD, PhD; Denis J. DiAngelo, PhD
A multibody dynamic simulation model was developed to emulate biomechanical testing of the human cervical spine. The kinematic and kinetic evaluations of the model during virtual biomechanical testings are discussed. With graphical illustrations and animation features, this modeling technique has provided vivid and intuitive information.
http://www.spinejournal.com/pt/re/spine/abstract.00007632-200705150-00018.htm



by laomu


Cervical Spine
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15、
E337 Immunohistochemical Demonstration of Advanced Glycation End Products and the Effects of Advanced Glycation End Products in Ossified Ligament Tissues In Vitro.
Kimiaki Yokosuka, MD; Jin Soo Park, MD, PhD; Kotaro Jimbo, MD, PhD; Tatuhiro Yoshida, MD; Kei Yamada, MD, PhD; Kimiaki Sato, MD, PhD; Masayoshi Takeuchi, PhD; Sho-ichi Yamagishi, MD, PhD; Kensei Nagata, MD, PhD
This report investigates the impact of advanced glycation end products on ossification of spinal ligaments (posterior longitudinal and yellow ligaments in vitro). Advanced glycation end products and advanced glycation end product receptors were identified within the posterior longitudinal and yellow ligaments using immunohistochemical analysis. Additionally, advanced glycation end products were found to increase significantly the expression of bone morphogenetic protein-2, bone morphogenetic protein-7, an osteoblast-specific transcription factor 1 (Cbfa1), and osteocalcin.
http://www.spinejournal.com/pt/re/spine/abstract.00007632-200705150-00018.htm



by zuoyazhong1979


Epidemiology
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16、
E340 Lumbar Ligamentum Flavum Hypertrophy Is Due to Accumulation of Inflammation-Related Scar Tissue.
Koichi Sairyo, MD, PhD; Ashok Biyani, MD; Vijay K. Goel, PhD; Douglas W. Leaman, PhD; Robert Booth Jr, MD; Jean Thomas, MD; Nabil A. Ebraheim, MD; Ian A. Cowgill, MS; Suneeth E. Mohan, BS
Accumulation of fibrosis (scarring) causes hypertrophy of the ligamentum flavum. A sign of inflammation, which is considered to be 1 of the initial events of scarring, was found in ligamentum flavum. Our findings suggest the possibility of controlling or preventing ligamentum flavum hypertrophy through the inhibition of the tissue inflammation.
http://www.spinejournal.com/pt/re/spine/abstract.00007632-200705150-00018.htm

Spine出版本期的同时，还出版了一期增刊，文章不多，虽然与临床不是十分密切，但对脊柱相关的研究方法，以及医疗相关的一些问题进行的研究和探讨，也还是很有意义的，因此也提供给各位战友，共同学习。

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May 15, 2007, Volume 32, Issue 11 Supplement
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Health Services Research
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17、
S2 To Err Is Human: Quality and Safety Issues in Spine Care.
David A. Wong, MD, MSc, FRCS(C); William C. Watters III, MD
Advocacy, patient safety, and quality spine care are interrelated. Advocacy initiatives pertaining to wrong site surgery, safety of new and existing technology, and patient safety legislation are reviewed. Be a patient safety advocate!
http://www.spinejournal.com/pt/re/spine/abstract.00007632-200705151-00002.htm

18、
S9 Measuring Outcomes in Back Care.
Timothy S. Carey, MD, MPH; Thelma J. Mielenz, PT, PhD, OCS
Multiple valid and reliable instruments are available for the assessment of back pain outcomes. These include domains of biologic measures, patient reports, process measures, and outcomes of interest to society. Bias can be introduced into outcomes assessment in many ways, attention to issues of study design, measurement, and analysis can lead to more valid and transparent research.
http://www.spinejournal.com/pt/re/spine/abstract.00007632-200705151-00003.htm



by huyingjiang

19、
S15 Evidence-Based Spine Surgery.
Daniel K. Resnick, MD
Evidence-based medicine methodologies may be applied to the literature concerning spinal surgery. The results of such structured reviews are useful for the justification of procedures that work and the discouragement of procedures that do not work. The strength of a recommendation is based solely on the quality of the primary literature. An important concept to keep in mind when performing or reviewing clinical practice guidelines is the fact that the absence of proof is not the proof of absence.
http://www.spinejournal.com/pt/re/spine/abstract.00007632-200705151-00004.htm



by hotstone

20、
S20 SF-36 PCS Benefit-Cost Ratio of Lumbar Fusion Comparison to Other Surgical Interventions: A Thought Experiment.
David W. Polly Jr, MD; Steven D. Glassman, MD; James D. Schwender, MD; Christopher I. Shaffrey, MD; Charles Branch, MD; J Kenneth Burkus, MD; Matthew F. Gornet; the Lumbar Spine Study Group
Lumbar spinal fusion has been well studied in Food and Drug Administration Investigational Device Exemption studies. These have shown consistent benefit in SF-36 PCS. This benefit compares favorably to total joint replacement and coronary artery bypass graft. In addition to using Medicare Provider Analysis and Review data, it is cost comparable per benefit gained.
http://www.spinejournal.com/pt/re/spine/abstract.00007632-200705151-00005.htm

21、
S27 Controlling Costs: Opportunities for Physician-Hospital Collaborations and Ventures.
Roby C. Thompson Jr, MD; Jennifer Reedstrom Bishop, JD
Certain gainsharing arrangements that permit hospitals to share definite cost savings with physicians have been approved by regulators, and are being looked at by hospitals and physicians to improve shrinking margins and increase revenue. Other structures may also be used where true gainsharing is not available or is too expensive to implement.
http://www.spinejournal.com/pt/re/spine/abstract.00007632-200705151-00006.htm

22、
S33 Pay-for-Performance: Considerations in Application to the Management of Spinal Disorders.
Sigurd Berven, MD; Amanda Smith, MA; Kevin Bozic, MD; David S. Bradford, MD
Pay-for-performance arrangements are intended to provide incentive for the implementation of evidence-based behavior in clinical practice. An effective pay-for-performance system applied to the management of spinal disorders will include a combination of measurable process variables and outcomes variables that reflect changes in health-related quality of life.
http://www.spinejournal.com/pt/re/spine/abstract.00007632-200705151-00007.htm


Technology Assessment
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23、
S39 Technology Assessment: Approach and Reimbursement.
Michael J. Yaszemski, MD, PhD; David W. Polly, MD; Scott D. Boden, MD; Gunnar B. J. Andersson, MD, PhD
Novel technologies are often included in new treatments for spine patients. The pathway to bringing such technologies to clinical practice includes input from clinicians, researchers, industry, regulatory agencies, and both governmental and private reimbursement agencies. Each of these must work in concert for improvements in treatment to reach patients.
http://www.spinejournal.com/pt/re/spine/abstract.00007632-200705151-00008.htm

24、
S44 The Spine Service Line: Optimizing Patient-Centered Spine Care.
Brian Kwon, MD; Scott G. Tromanhauser, MD; Robert J. Banco, MD
The spine service line requires coordination among providers. Developing a system to manage spine patients can be difficult but can lead to increased efficiency of care, lower financial burden, and morbidity from spinal disease. Institutional gain can be significant if managed appropriately.
http://www.spinejournal.com/pt/re/spine/abstract.00007632-200705151-00009.htm



by wyx790201

25、
S49 Physician-Owned Companies.
John P. Kostuik, MD
The author described his experience in dealing with, during practice, spine manufacturing corporations and related his experience in the development of a new company led by physicians, and describes regulatory and ethical dilemmas.
http://www.spinejournal.com/pt/re/spine/abstract.00007632-200705151-00010.htm



by sheepthief

26、
S53 Counterpoint: Physician-Industry Relationships Can Be Ethically Established, and Conflicts of Interest Can Be Ethically Managed.
Andrew P. White, MD; Alexander R. Vaccaro, MD, FACS; Thomas Zdeblick, MD
Effective collaboration between spine surgeons and industry improves patient care. Related conflicts of interest, however, must be ethically managed. This obligates disclosure and discussion of the quality of the medical evidence on which treatment recommendations are made. Existing and forthcoming guidelines can be used to direct management of conflicts.
http://www.spinejournal.com/pt/re/spine/abstract.00007632-200705151-00011.htm

27、
S58 Threats to Scientific Advancement in Clinical Practice.
James N. Weinstein, DO, MS
In the face of increasing academic and industry/business interdependency, the ethical road has only 1 signpost: disclose!
http://www.spinejournal.com/pt/re/spine/abstract.00007632-200705151-00012.htm



by sheepthief

。

。

Spine每期的第一页都有一幅非常迷人的风景照片，这期的是《Evening Skies of South Florida》，我贴上来供大家欣赏。
图片较大，我缩成60%了。原始图片的链接：
[url] http://my.freep.cn/R.asp?U=Dmy/070511/14/0705111450339596_88522.jpg [/url]