【文献推荐】uncorvering nuclear components in Wnt Pathway and epigenetics
这个帖子发布于 19 年零 73 天前，其中的信息可能已发生改变或有所发展。
早先的研究，Wnt通路的主要作用靶点是Lef-1 和TCF。 这个月第二期CELL上面发表了的文章揭示了细胞核内的另外一个蛋白质，Prop1 在 Wnt 的信号传到中起着关键作用而不是LEF1。
Homeodomain-Mediated β-Catenin-Dependent Switching Events Dictate Cell-Lineage Determination
Volume 125, Issue 3 , 5 May 2006, Pages 593-605
While the biological roles of canonical Wnt/β-catenin signaling in development and disease are well documented, understanding the molecular logic underlying the functionally distinct nuclear transcriptional programs mediating the diverse functions of β-catenin remains a major challenge. Here, we report an unexpected strategy for β-catenin-dependent regulation of cell-lineage determination based on interactions between β-catenin and a specific homeodomain factor, Prop1, rather than Lef/Tcfs. β-catenin acts as a binary switch to simultaneously activate expression of the critical lineage-determining transcription factor, Pit1, and to repress the gene encoding the lineage-inhibiting transcription factor, Hesx1, acting via TLE/Reptin/HDAC1 corepressor complexes. The strategy of functionally distinct actions of a homeodomain factor in response to Wnt signaling is suggested to be prototypic of a widely used mechanism for generating diverse cell types from pluripotent precursor cells in response to common signaling pathways during organogenesis
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Homeodomain-Mediated β-Catenin-Dependent Switching Events Dictate Cell-Lineage Determination
Volume 125, Issue 3 , 5 May 2006, Pages 593-605
While the biological roles of canonical Wnt/β-catenin signaling in development and disease are well documented, understanding the molecular logic underlying the functionally distinct nuclear transcriptional programs mediating the diverse functions of β-catenin remains a major challenge. Here, we report an unexpected strategy for β-catenin-dependent regulation of cell-lineage determination based on interactions between β-catenin and a specific homeodomain factor, Prop1, rather than Lef/Tcfs. β-catenin acts as a binary switch to simultaneously activate expression of the critical lineage-determining transcription factor, Pit1, and to repress the gene encoding the lineage-inhibiting transcription factor, Hesx1, acting via TLE/Reptin/HDAC1 corepressor complexes. The strategy of functionally distinct actions of a homeodomain factor in response to Wnt signaling is suggested to be prototypic of a widely used mechanism for generating diverse cell types from pluripotent precursor cells in response to common signaling pathways during organogenesis
发新帖请使用标签【文献推荐】【求助】【原创】【转载】【讨论】等
本版发帖须知及新手指南
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