equations如何理解？

Sedatives in specific populations is also a little studied area of critical care. One population that deserves mention because of the increasing prevalence is patients with obesity. The prevalence of obesity in the United State rose to 42.4% in 2017–2018, according to the CDC [15]. In general, titrating analgesics and sedatives to effect while strictly using ideal body weight or adjusted body weight for dosing is recommended to safely achieve clinically effective levels. However, standard nonweight-based dosing for antipsychotics is recommended because of pharmacokinetics that favor distribution to the adipose tissue [16 &&]. Physicians should have an understanding of the pharmacokinetics of common medications and be aware of the potential for under or overdosing. Critical care pharmacists are a useful resource when caring for these patients. Very limited data is available for drug dosing in the critical care setting in obese patients. Updated dosing equations may need to be developed. Given the continued rise in severe obesity in the United States, more study is needed. Sedation goals should be patient-centered and take into account patient comfort and medical comorbidities including obesity.

特定人群中镇静剂的使用也是重症监护一个很少研究的领域。由于患病率不断上升，有一类人群值得一提，那就是肥胖症患者。美国疾病控制与预防中心的数据显示，2017-2018年间美国肥胖率上升至42.4%。一般来说，推荐在使用理想体重或调整后的体重来估算剂量，同时严格滴定止痛剂和镇静剂来发挥作用，以安全地达到临床有效水平。然而，推荐不以体重为标准剂量来使用抗精神病药物，因为其药代动力学有利于分布到脂肪组织。医生应该了解常见药物的药代动力学，并意识到剂量不足或过量的可能性。重症监护药师可以帮助你更好地治疗这些患者。在重症监护环境中，肥胖症患者的用药数据非常有限。可能需要开发更新的剂量方案。鉴于美国严重肥胖率持续上升，还需要更多研究。镇静目标应该以患者为中心，并考虑到患者的舒适度和包括肥胖在内的医疗合并症。

equations如何理解？谢谢