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normalised怎么理解?

发布于 2022-05-23 · 浏览 7346 · IP 江苏江苏
这个帖子发布于 2 年零 344 天前,其中的信息可能已发生改变或有所发展。

Lung strain is a concept defined in an attempt to understand mechanisms whereby artificial ventilation leads to lung injury. The VT delivered (i.e., the change in lung volume) and the FRC to which it is delivered define the degree of strain. Driving pressure (DP) is the difference between plateau pressure and PEEP , and represents VT normalized to respiratory system compliance. Higher DP has been shown to be associated with poorer outcomes in ARDS (see Chapter 31). A meta-analysis of 2250 patients undergoing anaesthesia and artificial ventilation also found a higher DP to be associated with the development of PPCs,with a predictive value greater than that of VT. Defining useful bedside measures which accurately reflect physiological variables that can predict clinical outcomes is the subject of ongoing research.

肺应变是一个旨在了解人工通气导致肺损伤机制的概念。潮气量(即肺容量变化)和潮气量相对应的FRC定义应变大小。驱动压(driving pressure,ΔP)是平台压和PEEP之间的差值,代表标准化为呼吸系统顺应性的VT110。已证明较高的驱动压与ARDS的预后较差有关(参见第31章)111。一项对2250名麻醉和人工通气患者的荟萃分析也发现较高的驱动压与PPCs的发生有关,其预测价值大于潮气量。为考察术中通气对PPCs的影响而设计的跨试验在试验在方案、所研究的患者群体和结局措施等方面有相当大的变异。

查了原文

A recent advance in the field is evidence that VT normalised to respiratory system compliance (VT/CRS) represents the ventilation variable that best stratifies for survival in ARDS patients. The ratio VT/CRS defines the driving pressure (DP), which can be estimated from the difference between plateau pressure and PEEP in the absence of respiratory effort, as in fully paralysed patients. In ARDS patients, changes in VT and PEEP were not by themselves predictive of survival, except when they resulted in DP changes.13 Such results appear to challenge initial findings on the role of reduced VT to improve survival. A registry-based study on a large population of surgical patients undergoing general anaesthesia with mechanical ventilation also proposed driving pressure as an important correlate for major postoperative pulmonary complications,14 which are still prevalent in the protective ventilation era.


从里面看normalised就是除以的意思?

最后编辑于 2022-10-09 · 浏览 7346

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