Given是这么理解吗？

A number of RCTs were undertaken to investigate the effect of the combination therapy. Given hydrocortisone shortens the duration of vasopressor dependency in septic shock [8 &&,9], a RCT was conducted with hydrocortisone included in the control group (VITAMINS) [36 &,37]. The VITAMINS trial enrolled 216 patients with septic shock with the primary outcome of time alive and vasopressor-**** up to 7 days. When compared with hydrocortisone monotherapy, the combination of vitamin C, thiamine, and hydrocortisone did not affect the primary outcome (difference, ?0.6 h; 95% CI ?8.3 to 7.2; P¼0.83) [38 &&]. Several ongoing RCTs compare combination therapy to placebo or ‘usual care’. Some beneficial effects from corticosteroids on shock resolution are, therefore, anticipated in the absence of corticosteroids from the control group. Results from those trials should be cautiously interpreted as they may significantly overestimate the effect of vitamin C [36 &].

已进行了大量的RCT来研究联合治疗的效果。考虑到氢化可的松可缩短脓毒症休克后血管加压素依赖性的持续时间，故对照组(VITAMINS组)中也将氢化可的松包含在内后进行RCT。VITAMINS组纳入216名感染性休克患者，主要结果为截至第7天，存活率和不应用血管加压药物时间。与氢化可的松单药相比，联合应用维生素C、维生素B1和氢化可的松没有影响主要结局(差异,􏰂0.6h;95%可信区间􏰂-8.3至7.2;P=0.83)。一些正在进行的RCT研究对比联合治疗和安慰剂或“常规治疗”的区别。因此，在对照组中未使用糖皮质激素的情况下，可以预期糖皮质激素对休克消退的一些有益作用。这些试验的结果应该谨慎地解释，因为它们可能大大高估了维生素C的作用

Given是这么理解吗？谢谢