【分享】双特异型抗体书籍Bispecific antibodies，RolandE.Kontermann，2011

1  Bispecific Antibodies : Developments and Current Perspectives.........................................................................1

RolandE.Kontermann

2  Bispecific Antibodies from HybridHybridoma...........................................................................................................29

GerhardMoldenhauer

3  Generation of Bispecific Antibodies by Chemical Conjugation...........................................................................47

DiegoEllermanandJustinM.Scheer

4  Trivalent and TrispecificAntibody Derivatives for Cancer Therapy....................................................................65

ChristophStein,IngoSchubert,andGeorgH.Fey

5  Diabodies, Single-Chain Diabodies, and Their Derivatives..................................................................................83

DafneMu¨llerandRolandE.Kontermann

6  Bispecific SingleDomain Antibodies...........................................................................................................................101

PatrickChamesandDanielBaty

7  AlternativeScaffoldsasBispecificAntibodyMimetics...............................................................................................115

JohnLo¨fblomandFredrikY.Frejd

8  Tribodies: Fab–scFv Fusion Proteins as a Platform to Create Multifunctional Pharmaceuticals...........135

NicoMertens

9  The Design and Engineering of IgG-Like Bispecific Antibodies.......................................................................151

PeiJinandZhenpingZhu

10  Dual-Variable Domain Immunoglobulin (DVD-Ig™)Technology: A Versatile,Novel FormatfortheNext Generation of Dual-Targeting Biologics........................................................................................................................171

EditTarcsa,WolfgangFraunhofer,TariqGhayur,JochenSalfeld,andJijieGu

11  Two-in-One Antibodies................................................................................................................................................187

PatrickKoenigandGermaineFuh

12  The Dock-and-Lock (DNL) Approach to Novel Bispecific Antibodies..........................................................199

Chien-HsingChang,EdmundA.Rossi,RobertM.Sharkey,andDavidM.Goldenberg

13  Effector Cell Recruitment by Bispecific Antibodies.............................................................................................217

ChristianKellner,MatthiasPeipp,andThomasValerius

14  Bispecific Antibodies for Arming Activated T Cells and Other Effector Cells for Tumor Therapy......................................................................................................................................................................................243

LawrenceG.LumandArchanaThakur

15  Bispecific T Cell Engager for Cancer Therapy........................................................................................................273

PatrickA.Baeuerle,GerhardZugmaier,andDominikRu¨ttinger

16  Trifunctional Triomab ® Antibodies for Cancer Therapy...............................................................................289

HorstLindhofer,JuergenHess,andPeterRuf

17  Bispecific Antibodies for the Retargeting of Cytokines..................................................................................313

BrunoRobert,ChristelLarbouret,DavidAzria,Jean-PierreMach,andAndre´Pe`legrin

18  Bispecific Antibodies and Gene Therapy............................................................................................................327

DirkM.Nettelbeck

19  Bispecific Antibodies for Diagnostic Applications............................................................................................349

ArchanaParashar,SusmitaSarkar,AdvaitaGanguly,SaiKiranSharma,andMavanurR.Suresh