a cultured tissue construct comprising cultured dermal fibroblasts cells cultured under conditions to produce a layer of extracellular matrix(ECM) which is synthesized and assembled by the cultured fibroblast cells, which the cultured fibroblast cells contained within the synthesized ECM layer,wherein the ECM comprises:(1) fibrillar type I and type II collagen showing a packing organization of fibrils and fibril bundles exhibiting a quarter-staggered 67nm banding pattern; ...........(后面就会了)。