dxy logo
首页丁香园病例库全部版块
搜索
登录

是between---and---结构吗?

发布于 2023-03-20 · 浏览 1634 · IP 江苏江苏
这个帖子发布于 2 年零 45 天前,其中的信息可能已发生改变或有所发展。

The novel coronavirus disease 2019 (COVID-19) pandemic is a global crisis, challenging healthcare systems worldwide. Many patients present with a remarkable disconnect in rest between profound hypoxemia yet without proportional signs of respiratory distress (i.e. happy hypoxemia) and rapid deterioration can occur. This particular clinical presentation in COVID-19 patients contrasts with the experience of physicians usually treating critically ill patients in respiratory failure and ensuring timely referral to the intensive care unit can, therefore, be challenging. A thorough understanding of the pathophysiological determinants of respiratory drive and hypoxemia may promote a more complete comprehension of a patient’s clinical presentation and management. Preserved oxygen saturation despite low partial pressure of oxygen in arterial blood samples occur, due to leftward shift of the oxyhemoglobin dissociation curve induced by hypoxemia-driven hyperventilation as well as possible direct viral interactions with hemoglobin. Ventilation-perfusion mismatch, ranging from shunts to alveolar dead space ventilation, is the central hallmark and offers various therapeutic targets.

新型冠状病毒肺炎(COVID-19)大流行是一场全球性危机,对全球医疗系统构成重大挑战。许多患者在静息状态下有严重低氧血症,并可能快速恶化,但无相应的呼吸窘迫体征(即沉默性低氧血症),表现出明显的脱节。因此,COVID-19患者的这种特殊临床表现与医生通常治疗呼吸衰竭重症患者的经验截然不同,因此确保及时转诊该类患者至重症监护室可能具有挑战性。彻底了解呼吸驱动和低氧血症的病理生理学决定因素可能有助于更全面地理解患者的临床表现和管理。尽管动脉血样中氧分压较低,但由于低氧血症驱动的过度通气诱导的氧合血红蛋白解离曲线左移以及病毒可能与血红蛋白的直接相互作用,导致动脉血氧饱和度不变。通气-血流不匹配(从分流到肺泡死腔通气)是中心标志,这些病理生理学提供各种治疗靶点。


理论上是这个意思,但如果是between---and---结构?

Many patients present with a remarkable disconnect in rest between profound hypoxemia yet without proportional signs of respiratory distress (i.e. happy hypoxemia) and rapid deterioration can occur.

就是这个意思

在静息状态下,许多患者的严重低氧血症(但无相应的呼吸窘迫体征,即沉默性低氧血症)与可能的快速恶化间出现明显的脱节

“严重低氧血症”与“可能的快速恶化”间怎么脱节?

新型冠状病毒感染||新型冠状病毒肺炎 (454)

最后编辑于 2023-03-20 · 浏览 1634

6 收藏点赞

全部讨论0

默认最新
avatar
6
分享帖子
share-weibo分享到微博
share-weibo分享到微信
认证
返回顶部