布比卡因和肾上腺素用于腹腔镜下子宫肌瘤切除术
这个帖子发布于 20 年零 314 天前，其中的信息可能已发生改变或有所发展。
Bupivacaine plus epinephrine for laparoscopic myomectomy: a randomized placebo-controlled trial.
Obstet Gynecol. 2004 Aug;104(2):243-9.
Zullo F, Palomba S, Corea D, Pellicano M, Russo T, Falbo A, Barletta E, Saraco P, Doldo P, Zupi E.
Department of Obstetrics and Gynecology, University "Magna Graecia" of Catanzaro, Catanzaro, Italy.
OBJECTIVE: To evaluate the effectiveness of the injection of bupivacaine plus epinephrine before laparoscopic myomectomy. METHODS: Sixty premenopausal women with uterine leiomyomata were enrolled in a randomized controlled design and intraoperatively treated with injection of bupivacaine plus epinephrine (group A) or saline solution (group B) during laparoscopic myomectomy. Uterine size and volume, number of leiomyomata, hematological parameters, total operative time, enucleation time of each myoma, suturing time of the myomectomy, blood loss, degree of surgical difficulty, and postoperative pain were evaluated. Just before and after the injection of vasoconstrictive or saline solution, systolic and diastolic blood pressure and heart rate were recorded in each subject. RESULTS: Blood loss, total operative and enucleation time, and degree of surgical difficulty was significantly (P <.05) lower in group A than in group B. No difference was observed between groups in suturing time of the myomectomy. The number of vials of pain medication used postoperatively was significantly (P <.05) lower in group A than in group B. No differences in systolic and diastolic blood pressure or heart rate was recorded between the 2 groups. CONCLUSION: The injection of bupivacaine plus epinephrine during laparoscopic myomectomy is effective in reducing blood loss, total operative and enucleation time, degree of surgical difficulty, and postoperative pain. LEVEL OF EVIDENCE: I
布比卡因和肾上腺素用于腹腔镜下子宫肌瘤切除术：
一项随机、安慰剂对照研究
研究人员发现，在腹腔镜下行子宫肌瘤切除术时，注射一种含布比卡因和肾上腺素的缩血管溶液似乎减少了病人的失血，缩短了手术时间和减少了术后疼痛。过去的研究结果发现加压素也有相似作用，但因为此药有不良的心血管副作用，使得研究人员开始寻找另外的方法。本文作者使用了2年的布比卡因/肾上腺素溶液，取得了良好的临床结果，共60名绝经前女性被随机分为进行腹腔镜下子宫肌瘤切除时或注射该溶液或生理盐水（在切开子宫前注射到肌瘤下组织）。与注射生理盐水的相比，注射缩血管溶液减少了失血、总手术时间、肌瘤摘出时间和手术困难度（全部p < 0.05），但缝合时间没有差异。手术后，缩血管溶液组的病人所用的止痛药更少(p < 0.05)。两组的血压、心率没有差异。研究结果表明，腹腔镜下子宫肌瘤切除术时使用这种缩血管溶液可能对术中和术后都有好处。
Obstet Gynecol. 2004 Aug;104(2):243-9.
Zullo F, Palomba S, Corea D, Pellicano M, Russo T, Falbo A, Barletta E, Saraco P, Doldo P, Zupi E.
Department of Obstetrics and Gynecology, University "Magna Graecia" of Catanzaro, Catanzaro, Italy.
OBJECTIVE: To evaluate the effectiveness of the injection of bupivacaine plus epinephrine before laparoscopic myomectomy. METHODS: Sixty premenopausal women with uterine leiomyomata were enrolled in a randomized controlled design and intraoperatively treated with injection of bupivacaine plus epinephrine (group A) or saline solution (group B) during laparoscopic myomectomy. Uterine size and volume, number of leiomyomata, hematological parameters, total operative time, enucleation time of each myoma, suturing time of the myomectomy, blood loss, degree of surgical difficulty, and postoperative pain were evaluated. Just before and after the injection of vasoconstrictive or saline solution, systolic and diastolic blood pressure and heart rate were recorded in each subject. RESULTS: Blood loss, total operative and enucleation time, and degree of surgical difficulty was significantly (P <.05) lower in group A than in group B. No difference was observed between groups in suturing time of the myomectomy. The number of vials of pain medication used postoperatively was significantly (P <.05) lower in group A than in group B. No differences in systolic and diastolic blood pressure or heart rate was recorded between the 2 groups. CONCLUSION: The injection of bupivacaine plus epinephrine during laparoscopic myomectomy is effective in reducing blood loss, total operative and enucleation time, degree of surgical difficulty, and postoperative pain. LEVEL OF EVIDENCE: I
布比卡因和肾上腺素用于腹腔镜下子宫肌瘤切除术：
一项随机、安慰剂对照研究
研究人员发现，在腹腔镜下行子宫肌瘤切除术时，注射一种含布比卡因和肾上腺素的缩血管溶液似乎减少了病人的失血，缩短了手术时间和减少了术后疼痛。过去的研究结果发现加压素也有相似作用，但因为此药有不良的心血管副作用，使得研究人员开始寻找另外的方法。本文作者使用了2年的布比卡因/肾上腺素溶液，取得了良好的临床结果，共60名绝经前女性被随机分为进行腹腔镜下子宫肌瘤切除时或注射该溶液或生理盐水（在切开子宫前注射到肌瘤下组织）。与注射生理盐水的相比，注射缩血管溶液减少了失血、总手术时间、肌瘤摘出时间和手术困难度（全部p < 0.05），但缝合时间没有差异。手术后，缩血管溶液组的病人所用的止痛药更少(p < 0.05)。两组的血压、心率没有差异。研究结果表明，腹腔镜下子宫肌瘤切除术时使用这种缩血管溶液可能对术中和术后都有好处。
1 收藏点赞
