【资源】脾脏在神经损伤中具有重要地位
这个帖子发布于 16 年零 250 天前，其中的信息可能已发生改变或有所发展。
昨天在浙江大学听一个教授讲课,说脾脏切除能保护神经损伤,觉得非常有意思.请大家注意收集这方面的文献,我们可以讨论交流
1: J Neurosci Res. 2008 Aug 1;86(10):2227-34. Links
The spleen contributes to stroke-induced neurodegeneration.Ajmo CT Jr, Vernon DO, Collier L, Hall AA, Garbuzova-Davis S, Willing A, Pennypacker KR.
Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, Florida 33216, USA.
Stroke, a cerebrovascular injury, is the leading cause of disability and third leading cause of death in the world. Recent reports indicate that inhibiting the inflammatory response to stroke enhances neurosurvival and limits expansion of the infarction. The immune response that is initiated in the spleen has been linked to the systemic inflammatory response to stroke, contributing to neurodegeneration. Here we show that removal of the spleen significantly reduces neurodegeneration after ischemic insult. Rats splenectomized 2 weeks before permanent middle cerebral artery occlusion had a >80% decrease in infarction volume in the brain compared with those rats that were subjected to the stroke surgery alone. Splenectomy also resulted in decreased numbers of activated microglia, macrophages, and neutrophils present in the brain tissue. Our results demonstrate that the peripheral immune response as mediated by the spleen is a major contributor to the inflammation that enhances neurodegeneration after stroke.
PMID: 18381759 [PubMed - indexed for MEDLINE]
1: J Neurosci Res. 2008 Aug 1;86(10):2227-34. Links
The spleen contributes to stroke-induced neurodegeneration.Ajmo CT Jr, Vernon DO, Collier L, Hall AA, Garbuzova-Davis S, Willing A, Pennypacker KR.
Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, Florida 33216, USA.
Stroke, a cerebrovascular injury, is the leading cause of disability and third leading cause of death in the world. Recent reports indicate that inhibiting the inflammatory response to stroke enhances neurosurvival and limits expansion of the infarction. The immune response that is initiated in the spleen has been linked to the systemic inflammatory response to stroke, contributing to neurodegeneration. Here we show that removal of the spleen significantly reduces neurodegeneration after ischemic insult. Rats splenectomized 2 weeks before permanent middle cerebral artery occlusion had a >80% decrease in infarction volume in the brain compared with those rats that were subjected to the stroke surgery alone. Splenectomy also resulted in decreased numbers of activated microglia, macrophages, and neutrophils present in the brain tissue. Our results demonstrate that the peripheral immune response as mediated by the spleen is a major contributor to the inflammation that enhances neurodegeneration after stroke.
PMID: 18381759 [PubMed - indexed for MEDLINE]
