【medical-news】Caspase-14对护肤起重要作用
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Caspase-14 Plays Important Role in Skin Protection
Caspase-14对护肤起重要作用
http://www.medscape.com/viewarticle/557138
NEW YORK (Reuters Health) May 23 - Caspase-14 protects the skin against ultraviolet B photodamage and water loss, according to the results of studies in caspase-14 knockout mice, researchers in Belgium and the US report.
纽约路透社健康栏目5月23日消息，比利时和美国的研究者报道，根据对敲除caspase-14的小鼠研究结果显示，caspase-14具有抑制中波紫外线光损伤和水流失的护肤作用。
"Our work indicated that it is possible to identify specific biochemical pathways in the skin that control its integrity and barrier function," Dr. Wim Declercq and Dr. Peter Vandenabeele from Ghent University, told Reuters Health.
“我们的研究表明，对保持皮肤完整性和屏障作用的皮肤特定的生化路径的识别成为可能性。”根特大学的医师Wim Declercq和 Peter Vandenabeele说。
Drs. Declercq and Vandenabeele and colleagues investigated the role of caspase-14 by generating caspase-14-deficient mice by homologous recombination. Although caspase-14 expression was ablated in all epidermal tissues, there were no gross histological abnormalities in the deficient mice.
医师Wim Declercq和 Peter Vandenabeele及其同事使用同源重组的caspase-14缺陷小鼠研究caspase-14的作用。尽管剔除了整个表皮组织的caspase-14表达，但是缺陷小鼠没有整体组织学异常。
"The skin of newborn caspase-14-deficient mice was shinier and more lichenified than that of wild-type mice, the results indicate, and this difference persisted throughout adulthood," they report in the May 21st advance online publication of Nature Cell Biology.
发表于在线发行的自然细胞生物学杂志5月21日版报道，“研究结果显示，新生caspase-14缺陷小鼠的皮肤比野生株小鼠皮肤更亮、苔藓化更明显，这种差别持续了整个成年期。”
Deficiency in caspase-14 impaired the cleavage of (pro)filaggrin to filaggrin, which has an important role in epidermal barrier function, the researchers note. As a consequence, transepidermal water loss was about 20% higher in caspase-14-deficient mice.
研究者表示，中间丝相关蛋白对表皮屏障功能起重要作用，而缺乏caspase-14损伤了中间丝相关蛋白间的连接。因此caspase-14缺陷小鼠经表皮水份丢失增高约20%。
Moreover, the report indicates that caspase-14-deficient skin had 2 to 3 times as many sunburnt cells with apoptotic hallmarks as wild-type skin after ultraviolet B exposure.
"The observed differences between normal and caspase-14-deficient mice underscore the fact that caspase-14 is an important player in the skin protection against the DNA damaging properties of ultraviolet light and water loss," Drs. Declercq and Vandenabeele conclude.
而且，中波紫外线照射后caspase-14缺陷小鼠皮肤中具有凋亡标志的晒斑细胞是野生株小鼠皮肤中的2到3倍。医师Declercq 和 Vandenabeele总结说， “观察正常和caspase-14缺陷小鼠间的差异，突出了caspase-14作为抑制紫外线DNA损伤和水分流失的皮肤保护中重要参与者”。
"We will explore the possibilities of applying recombinant caspase-14 in creams to reduce skin aging or to improve skin barrier regeneration, e.g., after wounding, burning, or infection," they added. "Also during skin transplantation, application of caspase-14 or modulation of its expression by pharmacological molecules could accelerate the skin barrier recovery."
“我们探索应用含有重组caspase-14的乳膏来减轻如创伤、烧伤、感染后的皮肤老化或促进皮肤屏障的再生。以及皮肤移植时，应用caspase-14或通过分子药理学调节caspase-14的表达可以加速皮肤屏障的修复。”
"In addition," they conclude, "a search for molecules that regulate caspase-14 can be of importance for pharmaceutical or cosmeceutical applications that try to identify means to prevent sunburn or improve skin care."
“另外，为了探索防止晒伤或促进皮肤护理的方法，调节caspase-14的分子研究对应用于制药或化妆品方面是非常重要的。”
Nat Cell Biol 2007;doi:10.1038/ncb1597.
自然细胞生物学2007 ;doi:10.1038/ncb1597
Caspase-14对护肤起重要作用
http://www.medscape.com/viewarticle/557138
NEW YORK (Reuters Health) May 23 - Caspase-14 protects the skin against ultraviolet B photodamage and water loss, according to the results of studies in caspase-14 knockout mice, researchers in Belgium and the US report.
纽约路透社健康栏目5月23日消息，比利时和美国的研究者报道，根据对敲除caspase-14的小鼠研究结果显示，caspase-14具有抑制中波紫外线光损伤和水流失的护肤作用。
"Our work indicated that it is possible to identify specific biochemical pathways in the skin that control its integrity and barrier function," Dr. Wim Declercq and Dr. Peter Vandenabeele from Ghent University, told Reuters Health.
“我们的研究表明，对保持皮肤完整性和屏障作用的皮肤特定的生化路径的识别成为可能性。”根特大学的医师Wim Declercq和 Peter Vandenabeele说。
Drs. Declercq and Vandenabeele and colleagues investigated the role of caspase-14 by generating caspase-14-deficient mice by homologous recombination. Although caspase-14 expression was ablated in all epidermal tissues, there were no gross histological abnormalities in the deficient mice.
医师Wim Declercq和 Peter Vandenabeele及其同事使用同源重组的caspase-14缺陷小鼠研究caspase-14的作用。尽管剔除了整个表皮组织的caspase-14表达，但是缺陷小鼠没有整体组织学异常。
"The skin of newborn caspase-14-deficient mice was shinier and more lichenified than that of wild-type mice, the results indicate, and this difference persisted throughout adulthood," they report in the May 21st advance online publication of Nature Cell Biology.
发表于在线发行的自然细胞生物学杂志5月21日版报道，“研究结果显示，新生caspase-14缺陷小鼠的皮肤比野生株小鼠皮肤更亮、苔藓化更明显，这种差别持续了整个成年期。”
Deficiency in caspase-14 impaired the cleavage of (pro)filaggrin to filaggrin, which has an important role in epidermal barrier function, the researchers note. As a consequence, transepidermal water loss was about 20% higher in caspase-14-deficient mice.
研究者表示，中间丝相关蛋白对表皮屏障功能起重要作用，而缺乏caspase-14损伤了中间丝相关蛋白间的连接。因此caspase-14缺陷小鼠经表皮水份丢失增高约20%。
Moreover, the report indicates that caspase-14-deficient skin had 2 to 3 times as many sunburnt cells with apoptotic hallmarks as wild-type skin after ultraviolet B exposure.
"The observed differences between normal and caspase-14-deficient mice underscore the fact that caspase-14 is an important player in the skin protection against the DNA damaging properties of ultraviolet light and water loss," Drs. Declercq and Vandenabeele conclude.
而且，中波紫外线照射后caspase-14缺陷小鼠皮肤中具有凋亡标志的晒斑细胞是野生株小鼠皮肤中的2到3倍。医师Declercq 和 Vandenabeele总结说， “观察正常和caspase-14缺陷小鼠间的差异，突出了caspase-14作为抑制紫外线DNA损伤和水分流失的皮肤保护中重要参与者”。
"We will explore the possibilities of applying recombinant caspase-14 in creams to reduce skin aging or to improve skin barrier regeneration, e.g., after wounding, burning, or infection," they added. "Also during skin transplantation, application of caspase-14 or modulation of its expression by pharmacological molecules could accelerate the skin barrier recovery."
“我们探索应用含有重组caspase-14的乳膏来减轻如创伤、烧伤、感染后的皮肤老化或促进皮肤屏障的再生。以及皮肤移植时，应用caspase-14或通过分子药理学调节caspase-14的表达可以加速皮肤屏障的修复。”
"In addition," they conclude, "a search for molecules that regulate caspase-14 can be of importance for pharmaceutical or cosmeceutical applications that try to identify means to prevent sunburn or improve skin care."
“另外，为了探索防止晒伤或促进皮肤护理的方法，调节caspase-14的分子研究对应用于制药或化妆品方面是非常重要的。”
Nat Cell Biol 2007;doi:10.1038/ncb1597.
自然细胞生物学2007 ;doi:10.1038/ncb1597
