【文摘发布】伴有远处转移的胃癌有必要行胃切除术?
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Title: Gastric adenocarcinoma with distant metastasis: is gastrectomy necessary?
Author:Sarela AI, Yelluri S; Leeds Upper Gastrointestinal Cancer Multidisciplinary Team.
Resource: Arch Surg. 2007 Feb;142(2):143-9; discussion 149
Abstract:
HYPOTHESIS: For distant metastatic (M1) gastric adenocarcinoma, a policy to maximally avoid resection of the primary tumor is safe and efficacious. DESIGN: Cohort study. SETTING: Academic tertiary care center. PATIENTS: Sixty-seven (32%) of 211 consecutive patients with adenocarcinoma of the stomach or gastroesophageal junction had synchronous M1 disease on computed tomography or laparoscopy. Sixty-three patients with M1 disease were treated nonoperatively, and complete data sets were available for 40 men and 15 women (median age, 73 years). Pretreatment functional performance status was good in 67%. The primary tumor was at the gastroesophageal junction in 20% and was poorly differentiated in 60%. The M1 disease involved the peritoneum in 80% or was exclusively nonperitoneal in 20%. Systemic chemotherapy was administered to 67%. MAIN OUTCOME MEASURES: Incidence of subsequent invasive intervention for primary tumor-related complications and survival in 55 nonoperatively managed patients with M1 disease. RESULTS: Fourteen patients (25%) had intervention a median of 5 months after diagnosis. Eight patients had more than 1 intervention. Intervention was for gastric obstruction (20%), bleeding (7%), or perforation (2%). No patient underwent gastrectomy. Laparotomy was performed in 9%; the remainder had endoscopic or radiologic procedures or radiotherapy. There was no intervention-related mortality. Median survival was 7 months (95% confidence interval, 4-10 months). In Cox regression univariate analysis, good functional performance status, exclusively nonperitoneal metastasis, nonpoor differentiation, and chemotherapy predicted significantly longer survival; chemotherapy was the only independently significant predictive factor. CONCLUSIONS: Palliative interventions were performed in 25% of patients, with no mortality. Survival characteristics were similar to those of previous series of noncurative gastrectomy for M1 disease.
PMID:17309965
Author:Sarela AI, Yelluri S; Leeds Upper Gastrointestinal Cancer Multidisciplinary Team.
Resource: Arch Surg. 2007 Feb;142(2):143-9; discussion 149
Abstract:
HYPOTHESIS: For distant metastatic (M1) gastric adenocarcinoma, a policy to maximally avoid resection of the primary tumor is safe and efficacious. DESIGN: Cohort study. SETTING: Academic tertiary care center. PATIENTS: Sixty-seven (32%) of 211 consecutive patients with adenocarcinoma of the stomach or gastroesophageal junction had synchronous M1 disease on computed tomography or laparoscopy. Sixty-three patients with M1 disease were treated nonoperatively, and complete data sets were available for 40 men and 15 women (median age, 73 years). Pretreatment functional performance status was good in 67%. The primary tumor was at the gastroesophageal junction in 20% and was poorly differentiated in 60%. The M1 disease involved the peritoneum in 80% or was exclusively nonperitoneal in 20%. Systemic chemotherapy was administered to 67%. MAIN OUTCOME MEASURES: Incidence of subsequent invasive intervention for primary tumor-related complications and survival in 55 nonoperatively managed patients with M1 disease. RESULTS: Fourteen patients (25%) had intervention a median of 5 months after diagnosis. Eight patients had more than 1 intervention. Intervention was for gastric obstruction (20%), bleeding (7%), or perforation (2%). No patient underwent gastrectomy. Laparotomy was performed in 9%; the remainder had endoscopic or radiologic procedures or radiotherapy. There was no intervention-related mortality. Median survival was 7 months (95% confidence interval, 4-10 months). In Cox regression univariate analysis, good functional performance status, exclusively nonperitoneal metastasis, nonpoor differentiation, and chemotherapy predicted significantly longer survival; chemotherapy was the only independently significant predictive factor. CONCLUSIONS: Palliative interventions were performed in 25% of patients, with no mortality. Survival characteristics were similar to those of previous series of noncurative gastrectomy for M1 disease.
PMID:17309965
