铁死亡还是国自然热点吗

铁死亡是一种铁依赖性致死机制，可在多种疾病中激活。

虽然铁死亡是连续多年的科研热点，但是很多人可能对铁死亡还不是十分了解，今天给大家推一篇综述，对于铁死亡的情况介绍，本人认为比较详细。

题目以及摘要如下：

Regulation of ferroptosis by lipid metabolism

Abstract

Ferroptosis is an iron-dependent lethal mechanism that can be activated in disease and is a proposed target for cancer therapy. Ferroptosis is defined by the overwhelming accumulation of membrane lipid peroxides. Ferroptotic lipid peroxidation is initiated on internal membranes and then appears at the plasma membrane, triggering lethal ion imbalances and membrane permeabilization. Sensitivity to ferroptosis is governed by the levels of peroxidizable polyunsaturated lipids and associated lipid metabolic enzymes. A different network of enzymes and endogenous metabolites restrains lipid peroxidation by interfering with the initiation or propagation of this process. This emerging understanding is informing new approaches to treat disease by modulating lipid metabolism to enhance or inhibit ferroptosis.

Keywords: MUFA; PUFA; cell death; ferroptosis; lipid; metabolism.