不要贪嘴，少吃点，保持饥饿，健康长寿

少吃有利于健康这个概念似乎并不新鲜了，2019年，著名期刊 Nature Metabolism 杂志发表了德国马克斯·普朗克衰老生物学研究所、德国科隆大学、英国Babraham研究所和伦敦大学学院等单位合作的研究，题为“A nutritional memory effect counteracts the benefits of dietary restriction in old mice”。

为限制饮食有利于生命健康再填重要论证。

该研究表明，早年，也就是尽早的饮食习惯，会在动物体内形成记忆，更有助于健康长寿。有些朋友，到了年龄才想起限制饮食，锻炼，可能作用就不大了。

下午论文摘要：

Abstract

Dietary restriction (DR) during adulthood can greatly extend lifespan and improve metabolic health in diverse species. However, whether DR in mammals is still effective when applied for the first time at old age remains elusive. Here, we report results of a late-life DR-switch experiment using 800 mice. Female mice aged 24 months were switched from an ad libitum (AL) diet to DR or vice versa. Strikingly, the switch from DR to AL acutely increases mortality, whereas the switch from AL to DR causes only a weak and gradual increase in survival, suggesting the body has a memory of earlier nutrition. RNA sequencing in liver and brown and white adipose tissue (BAT and WAT, respectively) demonstrates a largely refractory transcriptional and metabolic response in fat tissue to DR after an AL diet, particularly in WAT, and a proinflammatory signature in aged preadipocytes, which is prevented by chronic DR feeding. Our results provide evidence for a ‘nutritional memory’ as a limiting factor for DR-induced longevity and metabolic remodelling of WAT in mammals.