PROTAC和分子胶降解靶蛋白机制

Schematic representation of PROTAC and Molecular Glue. a A PROTAC molecule consists of an E3 ligase-targeting ligand, a linker, and a POI-binding ligand. It simultaneously binds to the POI and the E3 ubiquitin ligase, and induces the polyubiquitination and degradation of the POI. b Molecular glue induces the interaction between a POI and an E3 ubiquitin ligase via binding to the E3 ubiquitin ligase, as illustrated, or the POI. Relative to PROTAC molecules, molecular glues do not have a linker and have a lower MW.

Cited form: Targeted protein degradation: mechanisms, strategies and application (2022)