大修回复信求助

大修，但是感觉审稿人的描述像是拒稿的措辞，就是不知道审稿人想要我们回复什么做什么，也没说补什么实验，在线求助！！！！

Overall, the subject appears relevant in the field of signaling mechanisms underlying ocular defects. However, the work seems a bit preliminary and would need to be corroborated by additional experiments focused on lrpap1 gene expression and on TGF-beta-induced phenotype in terms of cell proliferation and ultrastructure (eg: collagen fiber arrangement).

Major points

How much is an altered cell proliferation, in parallel with cell death, contributing to the ocular phenotype? Could TGF-beta treatment affect also cell proliferation, or is it acting specifically only on the cell death rate?

Is the arrangement of the collagen fibers somehow affected by the TFG-beta treatments?

就是回答问题就好？