大事件，人把猴痘传给狗了？
在看新闻，这个必须得分享一下了友友们：
简单展开一下：
总的来说就是，巴黎，两位同居的男性猴痘患者，在症状出现12天之后，他们的雄性狗子出现皮肤粘膜损伤，包括腹部脓疱和薄肛门溃疡。
我大震惊……
下图 AB是人类，CD是他们的狗子。
原文没说具体怎么传上了，只说这俩人是抱着狗子睡的……
原链接：https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)01487-8/fulltext
原文我贴一贴，英语好的直接看，不太好的可以点上面原链接一键翻译。
Evidence of human-to-dog transmission of monkeypox virus
Human monkeypox virus is spreading in Europe and the USA among individuals who have not travelled to endemic areas.1 On July 23, 2022, monkeypox was declared a Public Health Emergency of International Concern by WHO Director-General Tedros Adhanom Ghebreyesus.2 Human-to-human transmission of monkeypox virus usually occurs through close contact with the lesions, body fluids, and respiratory droplets of infected people or animals.3 The possibility of sexual transmission is being investigated, as the current outbreak appears to be concentrated in men who have sex with men and has been associated with unexpected anal and genital lesions.1, 4 Whether domesticated cats and dogs could be a vector for monkeypox virus is unknown. Here we describe the first case of a dog with confirmed monkeypox virus infection that might have been acquired through human transmission.
Two men who have sex with men attended Pitié-Salpêtrière Hospital, Paris, France, on June 10, 2022 (appendix). One man (referred to as patient 1 going forward) is Latino, aged 44 years, and lives with HIV with undetectable viral loads on antiretrovirals; the second man (patient 2) is White, aged 27 years, and HIV-negative. The men are non-exclusive partners living in the same household. They each signed a consent form for the use of their clinical and biological data, and for the publication of anonymised photographs. The men had presented with anal ulceration 6 days after sex with other partners. In patient 1, anal ulceration was followed by a vesiculopustular rash on the face, ears, and legs; in patient 2, on the legs and back. In both cases, rash was associated with asthenia, headaches, and fever 4 days later (figure A, B).FigureSkin and mucosal lesions in two male patients and their dog with confirmed monkeypox virus
Monkeypox virus was assayed by real-time PCR (LightCycler 480 System; Roche Diagnostics, Meylan, France). In patient 1, virus was detected in skin and oropharynx samples; whereas in patient 2, virus was detected in anal and oropharynx samples.
12 days after symptom onset, their male Italian greyhound, aged 4 years and with no previous medical disorders, presented with mucocutaneous lesions, including abdomen pustules and a thin anal ulceration (figure C, D; appendix). The dog tested positive for monkeypox virus by use of a PCR protocol adapted from Li and colleagues5 that involved scraping skin lesions and swabbing the anus and oral cavity. Monkeypox virus DNA sequences from the dog and patient 1 were compared by next-generation sequencing (MinION; Oxford Nanopore Technologies, Oxford, UK). Both samples contained virus of the hMPXV-1 clade, lineage B.1, which has been spreading in non-endemic countries since April, 2022, and, as of Aug 4, 2022, has infected more than 1700 people in France, mostly concentrated in Paris, where the dog first developed symptoms. Moreover, the virus that infected patient 1 and the virus that infected the dog showed 100% sequence homology on the 19·5 kilobase pairs sequenced.
The men reported co-sleeping with their dog. They had been careful to prevent their dog from contact with other pets or humans from the onset of their own symptoms (ie, 13 days before the dog started to present cutaneous manifestations).
In endemic countries, only wild animals (rodents and primates) have been found to carry monkeypox virus.6 However, transmission of monkeypox virus in prairie dogs has been described in the USA7 and in captive primates in Europe8 that were in contact with imported infected animals. Infection among domesticated animals, such as dogs and cats, has never been reported.
To the best of our knowledge, the kinetics of symptom onset in both patients and, subsequently, in their dog suggest human-to-dog transmission of monkeypox virus. Given the dog's skin and mucosal lesions as well as the positive monkeypox virus PCR results from anal and oral swabs, we hypothesise a real canine disease, not a simple carriage of the virus by close contact with humans or airborne transmission (or both). Our findings should prompt debate on the need to isolate pets from monkeypox virus-positive individuals. We call for further investigation on secondary transmissions via pets.
