Reassuring' data suggests Johnson & Johnson vaccine may still have a role to play against Covid-19

The US public and even some health experts may have underestimated the Covid-19 vaccine made by Janssen, a division of Johnson & Johnson, new data shows. And there's emerging evidence that it could still play an important role ahead.

新的数据显示，美国公众和一些健康专家可能低估了强生新冠疫苗。新的证据表明这款疫苗未来仍然可以起重要作用。

A study published Thursday in the medical journal JAMA Network Open found that the J&J vaccine remains durable and effective, even through the surge of cases caused by the Delta variant. It was 76% effective overall in preventing Covid-19 infections and 81% effective in preventing Covid-related hospitalizations. The study also showed that it provided lasting immunity at least six months after the shots.

JAMA Network Open 周三出版的一项研究发现：经历了德尔塔变异株引起的病例剧增，目前仍然持久有效。强生新冠疫苗预防新冠疾病总的有效率是76%，预防新冠疾病相关住院有效率81%。该研究还表明，注射一剂后能产生至少持续六个月的免疫力。

Dr. Angela Branche, an infectious disease specialist and associate professor of medicine at the University of Rochester, said the side effect profile of the J&J vaccine "remains something that's of concern for some groups where that risk is high." Women ages 30 to 49 years are at increased risk of this rare adverse event, the CDC says.

这款疫苗在一些人群中的副作用风险高依然引起关切。CDC说，这一少见的副作用（伴血小板减少血栓形成综合征）在30至49岁女性人群风险增加。

"For some groups where that risk of developing serious blood clots is not very high, like older adults, this may be a good strategy," Branche said.

有些人群中严重的血栓形成风险不太高，如老年人。

进一步的研究可以，按人群使用就可以降低风险。

Montefiori said the vaccine deserves more study.

这款疫苗值得更多的研究。

"I think there might still be a place for the J&J vaccine in the long-term picture of this pandemic," Montefiori said.

从本次疫情前景看，强生这款疫苗仍有一席之地。

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The J&J vaccine also might have "a particular edge," he said.

"The immune system is actually made of two arms: the antibodies side and the T cells. And the type of T cells that are critical for prevention of serious illness are called CD8 T cells," Barouch said. "The J&J vaccine raises better CD8 T cells than the Pfizer and other mRNA vaccines, so the J&J vaccine might have a particular edge for variants like Omicron that largely escaped from antibody responses.免疫系统实际有两套武器：一方面是抗体，另一方面是T细胞。一类被叫做CD8的T细胞在预防重症方面起重要作用。强生疫苗比辉瑞和其他公司的mRNA疫苗能更好地增加CD8T细胞，因此，强生疫苗对能很大程度逃脱抗体反应的欧米克戎变异株，或许会有特别的优势。

The mRNA vaccines deliver blueprints, essentially, that train your body trains to fight that particular infection and any similar infection down the road. Adenovirus-vector vaccines, like J&J's, use a virus that can act like a Trojan horse. But instead of soldiers jumping out, the adenovirus releases genes that encode the coronavirus' spike protein.

mRNA疫苗和强生公司的腺病毒载体疫苗作用机制有所不同。腺病毒载体疫苗能释放可以编码冠状病毒棘蛋白的基因。

未来强生疫苗联合mRNA疫苗可能会比较有优势。强生疫苗还有两个突出优势：每个疗程仅需注射一剂，不需要冷链保存。

详见：https://edition.cnn.com/2022/03/20/health/johnson-and-johnson-covid-19-vaccine/index.html