idiotype–idiotype是否应为idiotype–antiidioty
下面这句话来自“IMMUNOMODULATION OF AUTOIMMUNE AND INFLAMMATORY DISEASES WITH INTRAVENOUS IMMUNE GLOBULIN”。idiotype–idiotype是否应为idiotype–antiidiotype
Natural autoantibodies are more polyreactive than immune antibodies, in the sense that they can often bind to different antigens.6 Natural autoantibodies can also recognize and be recognized by other autoantibodies in the same person. Since there is a high level of natural autoantibodies in immune globulin, a considerable fraction of immune globulin consists of antibodies capable of interacting with idiotypes (serologically defined constituents of the variable region) (Fig. 1) of other antibodies in the preparation to form dimers with complementary idiotypes. The content in such dimers in the immune globulin pool increases with the number of donors in the pool. 7 The formation of idiotype–idiotype dimers may account for some of the clinical effects of immune globulin (see below).
天然自身抗体比免疫抗体更具多反应性,因为它们通常能与不同的抗原结合。6天然自身抗体也可以识别同一个人中的其他自身抗体并被其他自身抗体所识别。由于免疫球蛋白中存在高水平的天然自身抗体,免疫球蛋白的相当一部分由能够与制剂中其他抗体独特型(血清学定义的可变区成分)相互作用的抗体组成,(图1),与互补独特型形成二聚体。免疫球蛋白库中二聚体的含量随着供体数量的增加而增加。7独特型-抗独特型二聚体的形成可以解释免疫球蛋白的一些临床效应(见下文)。
最后编辑于 2022-10-09 · 浏览 572