这两个理解的对吗?
Vaginitis, Estrogen-Deficient
GENERAL Rx
• Vaginal estrogen: Comes in cream, tablet inserts, and impregnated silastic ring. Tablets or cream can be used daily for the first 2 weeks, then 1 to 2× per week for maintenance therapy. Progesterone for endometrial protection is not required for vaginal estrogen.
• Systemic hormone replacement therapy (HRT): Utilize lowest effective dose. Estrogen use should be reviewed every 3 to 6 mo, with an attempt to taper or discontinue its use. Comes as a patch or pill. If uterus present, opposing progesterone therapy for protection of endometrial lining, either continuous low-dose pills, cyclic pills, or progesterone intrauterine device.
• Ospemifene: Selective estrogen receptor modulator, some systemic side effects (hot flashes, possible risk of venous thromboembolism).
• Other: Prasterone vaginal dehydroepiandrosterone is approved though less widely studied; vaginal laser therapy is being studied but is not approved for treatment.
雌激素缺乏性阴道炎
一般处方
l 阴道用雌激素:有乳膏、阴塞片剂和硅橡胶浸渍环。片剂或乳膏可每日使用连用2周,然后每周1至2次维持治疗。阴道使用雌激素并不需要合并使用保护子宫内膜的黄体酮。
l 全身激素替代疗法(hormone replacement therapy,HRT):使用最低有效剂量。雌激素的使用应每3~6个月复查一次,然后试图慢慢减少或停止使用,使用贴片或药片的形式。如果有子宫的话,反对为了保护子宫内膜而用黄体酮治疗,无论是连续低剂量丸、周期性药丸还是黄体酮宫内装置。
l 奥培米芬(Ospemifene):选择性雌激素受体调节剂,可能有一些全身性副作用(潮热,可能有静脉血栓栓塞的风险)。
l 其他:普拉甾酮阴道脱氢表雄酮已得到批准,但研究较少;阴道激光疗法正在研究中,但没有批准治疗。
最后编辑于 2022-10-09 · 浏览 1001