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One of the main goals of pain modulation is to modify pain to a more tolerable level, rather than its complete eradication.Different pain management interventions were tried but have effects that are more adverse. Till date, the only reliable pain blockers are analgesics and anti-inflammatory drugs in the form of opioids and non-opioids. Despite this, most of the drugs are ineffective at various levels, furthermore, adding to complications. Thus, there is an urgent need for effective intervention with minimal side effects.

more adverse，和谁比，有更大的副作用？

后面一句更是莫名其妙，感觉这句话应该在Till date这句话的前面，才是语序正确的

疼痛调节的主要目标之一是将疼痛调节到更易耐受的水平，而不是完全消除疼痛。已有不同的疼痛管理干预措施，但这些疼痛管理的干预措施副作用更大。到目前为止，唯一可靠的止痛药是阿片镇痛药和非阿片类药物形式的抗炎药。即便如此，大多数药物在不同程度上都是无效的，而且增加了并发症。因此，迫切需要在副作用最小的情况下进行有效的干预。