Allo-immunization?
Treatment is usually unnecessary. Evidence of on-going hemolysis should be absent on follow-up testing. Postreaction screening will reveal the offending allo-antibody. Delayed reactions are usually less severe that acute reactions. Indeed, the diagnosis might be missed entirely—particularly if the patent has been discharged home. The severity depends on the pathologic potency of the offending allo-antibody (e.g., affinity and titer). Allo-immunization is of particular concern in pregnancy. In particular, an Rh negative mother can potentially be allo-immunized by an Rh positive fetus. Consequently, Rh negative mothers are routinely given Rho (D) immune globulin prophylactically. Sickle cell patients with a history of transfusions who develop a delayed transfusion reaction are at increased risk for a vaso-occlusive crisis. Hematologic testing including allo-antibody screening may be warranted if repeat pregnancy is planned or surgery is anticipated.
通常情况下(迟发型溶血性输血反应)不需要治疗的,在随访检查中应该不会再有持续溶血的迹象。溶血反应后的血液筛查将揭示该致病的同种抗体。迟发反应通常没有急性反应严重(译者注:原文是less…that…,应为less…than…)。事实上,诊断可能会被完全遗漏——特别是如果患者已经出院回家。其严重程度取决于致病同种抗体的病理效力(例如亲和力和效价)。同种免疫在妊娠期间尤其令人担忧。特别是,Rh阴性的母亲可能会对Rh阳性的胎儿产生潜在的同种抗体。因此,对于Rh阴性的母亲应该常规给予Rho(D)免疫球蛋白预防新生儿溶血。有输血史的镰状细胞血症患者一旦出现迟发型输血反应,发生血管闭塞危象的风险增加。如果计划再次妊娠或做手术,包括同种抗体筛查在内的血液学检查是合理的。
Allo-immunization到底该怎么理解?或者说怎么翻译?
https://wenku.baidu.com/view/a161e46658eef8c75fbfc77da26925c52cc5912c.html#
最后编辑于 2020-06-21 · 浏览 1990