fibrofog啥意思，纤维肌痛的？

Small hippocampi are seen in patients with posttraumatic stress disorder (PTSD) and severe depression.The hippocampus is needed for short-term memory storage and moderates autonomic arousal. Mood issues, such as anxiety, depression, and cognitive dysfunction, are often comorbidities with fibromyalgia and share neurotransmitter pathways in the brain,possibly contributing to the “fibrofog,” a complaint voiced by many patients. Poor cognition in fibromyalgia patients may be aggravated by compromised BDNF(brain derived neurotrophic factor) activity which is needed to make new synapses. Interestingly, aerobic exercise increases BDNF and may improve cognition.Changes in corticotrophin-releasing factor (CRF)receptor sensitivity also increase anxiety and high CRF activity causes hippocampal atrophy. Thus, fibromyalgia is a constellation of pain, fatigue, and poor sleep. Fibromyalgia may have a genetic predisposition and may be triggered by life events.