每日生物医药动态报道 2017年1月汇编

Liver-directed gene therapy delivered using adeno-associated viral (AAV) vectors to treat diseases such as hemophilia have advanced into human testing. The potential for continued technological improvements to expand the therapeutic applications of gene therapy to treat liver disorders and the remaining clinical challenges are examined in a comprehensive review article published in Human Gene Therapy.

Researchers have designed molecules with the potential to deliver healing power to stressed cells -- such as those involved in heart attacks. The research, at a cellular level in the lab, involves organic molecules that break down to release hydrogen sulfide when triggered by oxidative stress.

A new study shows cognitive decline may be influenced by the interaction of genetics and ... worms?

Mutations that have been linked to endometrial cancer can be found in the uterine lavage fluid of pre- and post-menopausal women both with and without detectable cancer, according to a study published in PLOS Medicine

Researchers at Washington University School of Medicine in St. Louis have found that although many smokers with serious mental illnesses would like to quit smoking, many psychiatrists and caseworkers aren't aware of their patients' wishes and, consequently, haven't prescribed medications or referred them to services to help them stop smoking.

Patient satisfaction has become an important quality measure in the US healthcare system. But some plastic surgeons question the value of subjective patient satisfaction ratings -- suggesting that they might even lead to lower-quality care in some situations, according to a special topic article in the January issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS).

Looking at before-and-after photos, plastic surgeons and nurses can't tell whether breast augmentation surgery was done using conventional round implants or newer anatomically shaped implants, reports a study in the January issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS).

A new study led by scientists from the Florida campus of The Scripps Research Institute (TSRI) sheds light on a signaling circuit in cells that drives therapy resistance in prostate cancer. The researchers found that targeting the components of this circuit suppresses advanced prostate cancer development.