【medical-news】JID:在年轻女性口腔HPV中皮肤型常见
发布于 2013-10-18 · 浏览 1382 · IP 黑龙江黑龙江
这个帖子发布于 11 年零 215 天前，其中的信息可能已发生改变或有所发展。
Background.?Little is known about theepidemiology of oral human papillomavirus (HPV) in Latin America.
Methods.?Women (N = 5838) aged 22-29 in thecontrol and vaccine arms of an HPV-16/18 vaccine trial in Costa Rica had oral,cervical, and anal specimens collected. Samples were tested for alpha mucosalHPV types (SPF10/LiPA25 version 1); a subset of oral samples (n = 500) wastested for cutaneous HPV types in the genera alpha, beta, gamma, mu, and nu.
Results.?In the control arm (n = 2926),1.9% of women had an oral alpha mucosal HPV detected, 1.3% had carcinogenicHPV, and 0.4% had HPV-16; similar patterns for non-16/18 HPV types wereobserved in the vaccine arm. Independent risk factors for any oral alphamucosal HPV among women in the control arm included marital status (adjustedodds ratio [AOR], 3.2; 95% confidence interval [CI], 1.8-5.7 for singlecompared to married/living as married), number of sexual partners (AOR, 2.4;95% CI, 1.0-6.1 for ≥4 partners compared to 0-1 partners), chronic sinusitis (AOR, 3.1;95% CI, 1.5-6.7), and cervical HPV infection (AOR, 2.6; 95% CI, 1.4-4.6).Detection of beta HPV was common (18.6%) and not associated with sexualactivity.
Conclusions.?Unlike cutaneous HPV types,alpha mucosal HPV types were uncommon in the oral region and were predominatelyassociated with sexual behavior.Clinical Trials Registration.
Methods.?Women (N = 5838) aged 22-29 in thecontrol and vaccine arms of an HPV-16/18 vaccine trial in Costa Rica had oral,cervical, and anal specimens collected. Samples were tested for alpha mucosalHPV types (SPF10/LiPA25 version 1); a subset of oral samples (n = 500) wastested for cutaneous HPV types in the genera alpha, beta, gamma, mu, and nu.
Results.?In the control arm (n = 2926),1.9% of women had an oral alpha mucosal HPV detected, 1.3% had carcinogenicHPV, and 0.4% had HPV-16; similar patterns for non-16/18 HPV types wereobserved in the vaccine arm. Independent risk factors for any oral alphamucosal HPV among women in the control arm included marital status (adjustedodds ratio [AOR], 3.2; 95% confidence interval [CI], 1.8-5.7 for singlecompared to married/living as married), number of sexual partners (AOR, 2.4;95% CI, 1.0-6.1 for ≥4 partners compared to 0-1 partners), chronic sinusitis (AOR, 3.1;95% CI, 1.5-6.7), and cervical HPV infection (AOR, 2.6; 95% CI, 1.4-4.6).Detection of beta HPV was common (18.6%) and not associated with sexualactivity.
Conclusions.?Unlike cutaneous HPV types,alpha mucosal HPV types were uncommon in the oral region and were predominatelyassociated with sexual behavior.Clinical Trials Registration.
最后编辑于 2022-10-09 · 浏览 1382
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