【摘要翻译】环氧化酶-2（Cox-2）在膀胱癌中的表达
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【Title】 [Cyclooxygenase-2-expression in bladder cancer: tumor-biological and clinical implications]
【Source】Aktuelle Urol. 2004 Aug;35(4):331-8.
【Author】Wulfing C, Eltze E, Von Struensee D, Wulfing P, Bode ME, Bettendorf O, Piechota H, Hertle L.Klinik und Poliklinik fur Urologie, Universitatsklinikum Munster. wulfing@uni-muenster.de
【Abstract】
PURPOSE: Cyclooxygenase-2 (Cox-2) contributes to the carcinogenesis of human tumors by various mechanisms. As Cox-2-expression has been found in most human neoplasms, selective Cox-2-inhibitors could be used as a molecular targeted therapy, and first clinical trials have already been initiated. Moreover, Cox-2-inhibitors have been shown to add to the activity of conventional cytotoxic therapies in experimental and clinical studies. We analyzed Cox-2-expression in bladder cancer and its implications on clinical parameters. MATERIALS AND METHODS: Cox-2-expression was evaluated immunohistochemically in 157 patients undergoing radical cystectomy. Sixty-two patients had received cisplatin-based treatment during follow-up, either as adjuvant therapy or for metastatic disease. Cox-2-expression was correlated with clinical and pathological parameters, survival data and outcome of chemotherapy. RESULTS: Cox-2 was expressed in 83.4 % of tumors. No association was found with TNM-staging and histological grading, but a significant relation to the histologic subtype (transitional vs. squamous cell carcinoma, p = 0.038) was present. Survival analysis showed no impact of Cox-2-expression on overall or disease-free survival. However, a subgroup of chemotherapy patients demonstrated a significant correlation of strong Cox-2-expression with worse overall survival time (p = 0.01). CONCLUSIONS: Cox-2-expression was found in the majority of invasive bladder tumors. For patients who underwent chemotherapy, a significant relation of Cox-2-expression and worse overall survival was demonstrated. Cox-2 seems to be an interesting molecular target for the diagnosis and therapy of bladder cancer. Further experimental and clinical studies are warranted to elucidate whether Cox-2-inhibition can serve as an additive therapy to chemotherapy of bladder cancer.
【翻译】
环氧化酶-2(Cox-2)在膀胱癌中的表达:肿瘤生物和临床意义.
目的:环氧化酶-2(Cox-2)通过不同的机制导致人类肿瘤的发生.大部分人类肿瘤中已经发现了Cox-2的表达.选择性Cox-2抑制剂可能将成为一种分子靶式疗法,而其临床实验已经在进行中.而且Cox-2-抑制剂在临床和实验研究中显示出了增强常规的细胞毒疗法的作用.我们分析了膀胱癌中Cox-2的表达和其临床参数的意义.
材料和方法:在已行根治性膀胱切除的157例患者中用免疫组化法评估Cox-2的表达.62例患者在随访中行以顺铂为主的治疗,这可作为一种辅助治疗,预防肿瘤的转移.Cox-2的表达和临床及病理参数,存活数据,化疗效果相关.
结果:Cox-2在83.4 %的膀胱癌患者中有表达,且和肿瘤TNM分期及组织分级没有相关,但和肿瘤的组织类型相关(移行细胞癌VS鳞癌,P=0.038).生存分析表明Cox-2的表达对总存活数和无瘤存活率无影响.然而在行化疗的一小组中却表明Cox-2的强表达和总存活时间较差显著相关(P=0.01).
结论:在大部分浸润性膀胱肿瘤中Cox-2均有表达.对于行化疗的患者,Cox-2的表达和总存活数显著相关.Cox-2似乎为膀胱肿瘤诊断和治疗的一个有意义的分子目标.而Cox-2抑制剂能否作为膀胱肿瘤化疗的一辅助治疗方法,仍需要更多的实验和临床研究来评价和证实.
Cox-2抑制剂能否作为膀胱肿瘤化疗外的辅助治疗.
【全文】
http://www.dxy.cn/bbs/user/download/2446258/cox-2.pdf
【Source】Aktuelle Urol. 2004 Aug;35(4):331-8.
【Author】Wulfing C, Eltze E, Von Struensee D, Wulfing P, Bode ME, Bettendorf O, Piechota H, Hertle L.Klinik und Poliklinik fur Urologie, Universitatsklinikum Munster. wulfing@uni-muenster.de
【Abstract】
PURPOSE: Cyclooxygenase-2 (Cox-2) contributes to the carcinogenesis of human tumors by various mechanisms. As Cox-2-expression has been found in most human neoplasms, selective Cox-2-inhibitors could be used as a molecular targeted therapy, and first clinical trials have already been initiated. Moreover, Cox-2-inhibitors have been shown to add to the activity of conventional cytotoxic therapies in experimental and clinical studies. We analyzed Cox-2-expression in bladder cancer and its implications on clinical parameters. MATERIALS AND METHODS: Cox-2-expression was evaluated immunohistochemically in 157 patients undergoing radical cystectomy. Sixty-two patients had received cisplatin-based treatment during follow-up, either as adjuvant therapy or for metastatic disease. Cox-2-expression was correlated with clinical and pathological parameters, survival data and outcome of chemotherapy. RESULTS: Cox-2 was expressed in 83.4 % of tumors. No association was found with TNM-staging and histological grading, but a significant relation to the histologic subtype (transitional vs. squamous cell carcinoma, p = 0.038) was present. Survival analysis showed no impact of Cox-2-expression on overall or disease-free survival. However, a subgroup of chemotherapy patients demonstrated a significant correlation of strong Cox-2-expression with worse overall survival time (p = 0.01). CONCLUSIONS: Cox-2-expression was found in the majority of invasive bladder tumors. For patients who underwent chemotherapy, a significant relation of Cox-2-expression and worse overall survival was demonstrated. Cox-2 seems to be an interesting molecular target for the diagnosis and therapy of bladder cancer. Further experimental and clinical studies are warranted to elucidate whether Cox-2-inhibition can serve as an additive therapy to chemotherapy of bladder cancer.
【翻译】
环氧化酶-2(Cox-2)在膀胱癌中的表达:肿瘤生物和临床意义.
目的:环氧化酶-2(Cox-2)通过不同的机制导致人类肿瘤的发生.大部分人类肿瘤中已经发现了Cox-2的表达.选择性Cox-2抑制剂可能将成为一种分子靶式疗法,而其临床实验已经在进行中.而且Cox-2-抑制剂在临床和实验研究中显示出了增强常规的细胞毒疗法的作用.我们分析了膀胱癌中Cox-2的表达和其临床参数的意义.
材料和方法:在已行根治性膀胱切除的157例患者中用免疫组化法评估Cox-2的表达.62例患者在随访中行以顺铂为主的治疗,这可作为一种辅助治疗,预防肿瘤的转移.Cox-2的表达和临床及病理参数,存活数据,化疗效果相关.
结果:Cox-2在83.4 %的膀胱癌患者中有表达,且和肿瘤TNM分期及组织分级没有相关,但和肿瘤的组织类型相关(移行细胞癌VS鳞癌,P=0.038).生存分析表明Cox-2的表达对总存活数和无瘤存活率无影响.然而在行化疗的一小组中却表明Cox-2的强表达和总存活时间较差显著相关(P=0.01).
结论:在大部分浸润性膀胱肿瘤中Cox-2均有表达.对于行化疗的患者,Cox-2的表达和总存活数显著相关.Cox-2似乎为膀胱肿瘤诊断和治疗的一个有意义的分子目标.而Cox-2抑制剂能否作为膀胱肿瘤化疗的一辅助治疗方法,仍需要更多的实验和临床研究来评价和证实.
Cox-2抑制剂能否作为膀胱肿瘤化疗外的辅助治疗.
【全文】
http://www.dxy.cn/bbs/user/download/2446258/cox-2.pdf
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