【摘要翻译】膀胱肿瘤转移的标志物
这个帖子发布于 20 年零 251 天前，其中的信息可能已发生改变或有所发展。
【Title】Metastasis markers in bladder cancer: a review of the literature and clinical considerations.
【Journal】Eur Urol. 2004 Sep;46(3):296-311.
【Author】Gontero P, Banisadr S, Frea B, Brausi M.
Department of Urology, Universita del Piemonte Orientale, Novara, Italy. paolo.gontero@med.unipmn.it
【Abstract】
Cancer invasion and metastasis develop through a sequence of processes involving loss of cell-cell and cell-matrix adhesions, proteolysis and induction of angiogenesis. We reviewed the current literature on the molecules that have been shown to play a significant role in these three steps of metastatisation in bladder cancer (BC) cells and their host microenvironment. Particular emphasis was given to markers that are assessable through immunohistochemistry and for which an additional prognostic value over the TNM variables has been recognized, in order to identify a subset of tumour markers readily available for application in daily clinical practice. We conclude that markers such as E-cadherin, Sialosyl-LeX, laminin, collagen IV, TSP-1 and MVD are useful prognostic markers, alpha, beta, and gamma catenin, MMP-2 and -9, uPAR, PD-ECGF and Bfgf can be considered potentially useful, while research on CD44, MMP-1 and -3, uPA, cathepsin D and VEGF has proved inconclusive. Further research in this field should concentrate on the molecules listed in the first group.
【翻译】 膀胱肿瘤转移的标志物:对相关文献和临床注意事项的综述
肿瘤浸润和转移要经过一序列的过程包括细胞-细胞,细胞-基质之间的粘附物的丢失,蛋白水解作,和诱导血管生成.我们复习了现在关于在膀胱肿瘤转移的三个步骤中起重要作用的分子及其微环境的文献.并特别强调了采用免疫组化能检测到的标志物,这是因为人们认识了肿瘤TNM分期的变化,这些标志物具有判断预后的价值并且能够应用于日常的诊疗活动.我们总结出象E-cadherin(E-钙粘蛋白),laminin(层粘连蛋白),collagen IV(胶原IV),TSP-1(血小板反应蛋白-1)等为有用的判断预后的标志物.alpha, beta, and gamma 连环蛋白,间质金属蛋白酶-2和9,基本成纤维细胞生长因子等可能有潜在的应用价值,然而对这些标志物的研究还没有定论.在这领域内的深入研究应该集中在E-cadherin(E-钙粘蛋白),laminin(层粘连蛋白),collagen IV(胶原IV),TSP-1(血小板反应蛋白-1)等.
【导读】这篇文献主要综述了与膀胱肿瘤的转移有关的标志物，有兴趣的朋友可以一读.
【全文链接】Metastasis markers in bladder cancer: a review of the literature and clinical considerations
【Journal】Eur Urol. 2004 Sep;46(3):296-311.
【Author】Gontero P, Banisadr S, Frea B, Brausi M.
Department of Urology, Universita del Piemonte Orientale, Novara, Italy. paolo.gontero@med.unipmn.it
【Abstract】
Cancer invasion and metastasis develop through a sequence of processes involving loss of cell-cell and cell-matrix adhesions, proteolysis and induction of angiogenesis. We reviewed the current literature on the molecules that have been shown to play a significant role in these three steps of metastatisation in bladder cancer (BC) cells and their host microenvironment. Particular emphasis was given to markers that are assessable through immunohistochemistry and for which an additional prognostic value over the TNM variables has been recognized, in order to identify a subset of tumour markers readily available for application in daily clinical practice. We conclude that markers such as E-cadherin, Sialosyl-LeX, laminin, collagen IV, TSP-1 and MVD are useful prognostic markers, alpha, beta, and gamma catenin, MMP-2 and -9, uPAR, PD-ECGF and Bfgf can be considered potentially useful, while research on CD44, MMP-1 and -3, uPA, cathepsin D and VEGF has proved inconclusive. Further research in this field should concentrate on the molecules listed in the first group.
【翻译】 膀胱肿瘤转移的标志物:对相关文献和临床注意事项的综述
肿瘤浸润和转移要经过一序列的过程包括细胞-细胞,细胞-基质之间的粘附物的丢失,蛋白水解作,和诱导血管生成.我们复习了现在关于在膀胱肿瘤转移的三个步骤中起重要作用的分子及其微环境的文献.并特别强调了采用免疫组化能检测到的标志物,这是因为人们认识了肿瘤TNM分期的变化,这些标志物具有判断预后的价值并且能够应用于日常的诊疗活动.我们总结出象E-cadherin(E-钙粘蛋白),laminin(层粘连蛋白),collagen IV(胶原IV),TSP-1(血小板反应蛋白-1)等为有用的判断预后的标志物.alpha, beta, and gamma 连环蛋白,间质金属蛋白酶-2和9,基本成纤维细胞生长因子等可能有潜在的应用价值,然而对这些标志物的研究还没有定论.在这领域内的深入研究应该集中在E-cadherin(E-钙粘蛋白),laminin(层粘连蛋白),collagen IV(胶原IV),TSP-1(血小板反应蛋白-1)等.
【导读】这篇文献主要综述了与膀胱肿瘤的转移有关的标志物，有兴趣的朋友可以一读.
【全文链接】Metastasis markers in bladder cancer: a review of the literature and clinical considerations
回复2 点赞
