Lichen Slerosus et Atrophicus vs. Scleroderma
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Lichen Slerosus et Atrophicus vs. Scleroderma
Lichen Slerosus et Atrophicus
1. Marked laminated or compact orthokeratosis of the stratum corneum
2. Infundibula and acrosyringia plugged by orthokeratotic cells often
3. Thinned epidermis with loss of the normal pattern between epidermal rete ridges and dermal papillae
4. Epidermal melanin decreased uniformly
5. Vacuolar alteration at the dermo-epidermal junction
6. Papillary dermis markedly thickened and homogenized
7. Reticular dermis relatively unaffected
8. Moderately dense perivascular, predominantly lympho-histiocytic infiltrate with occasional plasma cells beneath thickened papillary dermis
9. Epithelial structures of adnexa mostly preserved
10. No involvement of the subcutaneous fat
11. No fasciitis
Scleroderma
1. Normal stratum corneum
2. Adnexal ostia not plugged as a rule; may be plugged sometimes
3. Preservation of normal epidermis and pattern between epidermis and dermis
4. Epidermal melanin decreased and increased focally in some lesions
5. Little or no vacuolar alteration
6. Papillary dermis relatively unaffected in most, but not all, lesions
7. Reticular dermis thickened by bundles of sclerotic collagen arranged compactly and parallel to the skin surface
8. Moderately dense superficial and deep perivascular and sometimes interstitial infiltrate of lymphocytes, histiocytes, plasma cells, and rarely eosinophils
9. Epithelial structures of adnexa mostly destroyed
10. Septal panniculitis and subsequent thickening and sclerosis of septa
11. Fasciitis occasionally; process may extend into skeletal muscle and even into bone.
Lichen Slerosus et Atrophicus
1. Marked laminated or compact orthokeratosis of the stratum corneum
2. Infundibula and acrosyringia plugged by orthokeratotic cells often
3. Thinned epidermis with loss of the normal pattern between epidermal rete ridges and dermal papillae
4. Epidermal melanin decreased uniformly
5. Vacuolar alteration at the dermo-epidermal junction
6. Papillary dermis markedly thickened and homogenized
7. Reticular dermis relatively unaffected
8. Moderately dense perivascular, predominantly lympho-histiocytic infiltrate with occasional plasma cells beneath thickened papillary dermis
9. Epithelial structures of adnexa mostly preserved
10. No involvement of the subcutaneous fat
11. No fasciitis
Scleroderma
1. Normal stratum corneum
2. Adnexal ostia not plugged as a rule; may be plugged sometimes
3. Preservation of normal epidermis and pattern between epidermis and dermis
4. Epidermal melanin decreased and increased focally in some lesions
5. Little or no vacuolar alteration
6. Papillary dermis relatively unaffected in most, but not all, lesions
7. Reticular dermis thickened by bundles of sclerotic collagen arranged compactly and parallel to the skin surface
8. Moderately dense superficial and deep perivascular and sometimes interstitial infiltrate of lymphocytes, histiocytes, plasma cells, and rarely eosinophils
9. Epithelial structures of adnexa mostly destroyed
10. Septal panniculitis and subsequent thickening and sclerosis of septa
11. Fasciitis occasionally; process may extend into skeletal muscle and even into bone.
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