【进展】慢性乙肝的治疗性疫苗和基于免疫的治疗方案： 前瞻和挑战
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Therapeutic vaccines and immune-based therapies for the
treatment of chronic hepatitis B: perspectives and challenges
慢性乙肝的治疗性疫苗和基于免疫的治疗方案：前瞻和挑战
摘要
The treatment of chronic hepatitis B virus (HBV) infection has greatly improved over the last
10 years, but alternative treatments are still needed. Therapeutic vaccination is a promising
new strategy for controlling chronic infection. However, this approach has not been as
successful as initially anticipated for chronic hepatitis B. General impairment of the immune
responses generated during persistent HBV infection, with exhausted T cells not responding
correctly to therapeutic vaccination, is probably responsible for the poor clinical responses
observed to date. Intensive research efforts are now focusing on increasing the efficacy of
therapeutic vaccination without causing liver disease. We describe here new approaches, for
use with therapeutic vaccination, to overcome the inhibitory mechanisms impairing immune
responses. We also describe innovative strategies for generating functional immune responses
and inducing sustained control of this persistent infection.
乙肝的治疗在过去的10年里有了很大的改善，但是仍然需要有的新的治疗方案。治疗性疫苗是一个新的非常有前景的控制慢性感染的策略，但是，对慢性乙肝该方案并不如同最初的期望那样成功。通常，长期的乙肝感染可以导致免疫反应的损伤，耗竭的T细胞并不准确的对治疗性疫苗响应，这可能可以解释目前观察到的差的响应。目前，大部分研究的努力都聚集在提高治疗性疫苗的有效率，但同时避免一起肝部疾病。我们在这里描述一种新的途径，使用治疗性疫苗，从而来克服破坏免疫系统的抑制机制（inhibitory mechanisms）。
我们同时描述了一项新的策略用于产生功能性的免疫反应并可以导致持续性的控制残留顽固的感染。
Key words: hepatitis B, chronic infection, immunotherapy, vaccine, DNA vaccine, T-cell
therapy, clinical trial
关键词：乙肝，慢性感染，免疫治疗，疫苗，DNA疫苗，T细胞治疗，临床试验
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