【Nature】自噬通过细胞自我消化作用抵抗疾病
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自噬通过细胞自我消化作用抵抗疾病
Mizushima N, Levine B, Cuervo AM，ET AL：Autophagy fights disease through cellular self-digestion. Nature. 2008 Feb 28;451(7182):****-75.
Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo 113-8519, Japan.
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Abstract
Autophagy, or cellular self-digestion, is a cellular pathway involved in protein and organelle degradation, with an astonishing number of connections to human disease and physiology.
For example, autophagic dysfunction is associated with cancer, neurodegeneration, microbial infection and ageing.
Paradoxically, although autophagy is primarily a protective process for the cell,
it can also play a role in cell death. Understanding autophagy may ultimately allow scientists and clinicians to harness this process for the purpose of improving human health.
Mizushima N, Levine B, Cuervo AM，ET AL：Autophagy fights disease through cellular self-digestion. Nature. 2008 Feb 28;451(7182):****-75.
Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo 113-8519, Japan.
----------------------------------------------------------------------------
Abstract
Autophagy, or cellular self-digestion, is a cellular pathway involved in protein and organelle degradation, with an astonishing number of connections to human disease and physiology.
For example, autophagic dysfunction is associated with cancer, neurodegeneration, microbial infection and ageing.
Paradoxically, although autophagy is primarily a protective process for the cell,
it can also play a role in cell death. Understanding autophagy may ultimately allow scientists and clinicians to harness this process for the purpose of improving human health.
