【下载】肝豆状核变性“熊猫脸”头颅核磁
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肝豆状核变性头颅核磁为熊猫脸样变化，以前听其他老师讲过，但没见到典型病例，近期在学习国外文献中有一篇文献中描述神经系统病变时配一病例，真是典型的熊猫脸，而且在中脑部位，大家看一下。引自Nature Clinical Practice Neurology (2006) 2, 482-493
doi:10.1038/ncpneuro0291
Some WD-related changes exhibit characteristic features on MRI, for instance 'face of the giant panda', which is seen in T2-weighted images of the midbrain and 'face of the miniature panda', which can be seen in the tegmentum region of the pons in the same sequence. Sometimes, T2-weighted images show hypointensity in the basal ganglia region as a result of deposition of iron in exchange for copper after chelation. MRI findings can be similar to those seen in several other disorders, including Leigh disease, hypoxic–ischemic encephalopathy, methyl alcohol poisoning, Japanese B encephalitis, and selective extrapontine myelinolysis caused by osmotic disequilibrium syndrome. It is essential, therefore, to correlate the imaging with clinical features and biochemical markers of WD.
doi:10.1038/ncpneuro0291
Some WD-related changes exhibit characteristic features on MRI, for instance 'face of the giant panda', which is seen in T2-weighted images of the midbrain and 'face of the miniature panda', which can be seen in the tegmentum region of the pons in the same sequence. Sometimes, T2-weighted images show hypointensity in the basal ganglia region as a result of deposition of iron in exchange for copper after chelation. MRI findings can be similar to those seen in several other disorders, including Leigh disease, hypoxic–ischemic encephalopathy, methyl alcohol poisoning, Japanese B encephalitis, and selective extrapontine myelinolysis caused by osmotic disequilibrium syndrome. It is essential, therefore, to correlate the imaging with clinical features and biochemical markers of WD.
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