【medical-news】合并Churg-Strauss症候群哮喘患者常有气流阻塞
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· Airflow obstruction common in asthmatics with Churg-Strauss syndrome
合并Churg-Strauss症候群哮喘患者常见气流阻塞
MedWire News: Chronic airflow obstruction due to uncontrolled asthma affects more than a third of patients with Churg-Strauss syndrome, despite corticosteroid use, study findings indicate.
Churg-Strauss syndrome is characterized by eosinophil dysfunction leading to vascular damage in the airways and elsewhere, as well as asthma. Most patients with the syndrome need long-term treatment with low doses of corticosteroids to control their asthma after correcting the eosinophilic dysfunction.
However, “the outcome of asthma in Churg-Strauss syndrome has hitherto not been studied, although it is included in the definition of the syndrome and is severe,” note Vincent Cottin (University of Lyon, France) and colleagues in the journal Allergy.
Cottin and team therefore retrospectively examined data from 24 consecutive patients with Churg-Strauss syndrome all of whom had been treated at the same institution.
As expected, all patients were asthmatic and had been so for an average of 8 years before being diagnosed with Churg-Strauss syndrome.
When first diagnosed with the syndrome, 70% of the patients had airway obstruction, by the time syndrome remission had been achieved this figure was reduced to 50%.
However, approximately 3 years after first being diagnosed with Churg-Strauss syndrome, and despite chronic corticosteroid use over this time, 38% of patients still had airflow obstruction.
Summarizing, the authors concede that their findings are limited because their study was retrospective and lacked long-term follow-up data for some patients.
In addition, although the current findings suggest a higher rate of airflow obstruction in asthmatics with Churg-Strauss syndrome than is normally found in asthmatics without the syndrome, this comparison was not made in the current analysis.
Finally, the investigators note that “whether a more vigorous treatment of asthma may lead to a better long-term outcome of asthma in Churg-Strauss Syndrome remains to be determined.”
Source :
Current Medicine Group (AZN101636)
Allergy 2009; 64: 589–595
合并Churg-Strauss症候群哮喘患者常见气流阻塞
MedWire News: Chronic airflow obstruction due to uncontrolled asthma affects more than a third of patients with Churg-Strauss syndrome, despite corticosteroid use, study findings indicate.
Churg-Strauss syndrome is characterized by eosinophil dysfunction leading to vascular damage in the airways and elsewhere, as well as asthma. Most patients with the syndrome need long-term treatment with low doses of corticosteroids to control their asthma after correcting the eosinophilic dysfunction.
However, “the outcome of asthma in Churg-Strauss syndrome has hitherto not been studied, although it is included in the definition of the syndrome and is severe,” note Vincent Cottin (University of Lyon, France) and colleagues in the journal Allergy.
Cottin and team therefore retrospectively examined data from 24 consecutive patients with Churg-Strauss syndrome all of whom had been treated at the same institution.
As expected, all patients were asthmatic and had been so for an average of 8 years before being diagnosed with Churg-Strauss syndrome.
When first diagnosed with the syndrome, 70% of the patients had airway obstruction, by the time syndrome remission had been achieved this figure was reduced to 50%.
However, approximately 3 years after first being diagnosed with Churg-Strauss syndrome, and despite chronic corticosteroid use over this time, 38% of patients still had airflow obstruction.
Summarizing, the authors concede that their findings are limited because their study was retrospective and lacked long-term follow-up data for some patients.
In addition, although the current findings suggest a higher rate of airflow obstruction in asthmatics with Churg-Strauss syndrome than is normally found in asthmatics without the syndrome, this comparison was not made in the current analysis.
Finally, the investigators note that “whether a more vigorous treatment of asthma may lead to a better long-term outcome of asthma in Churg-Strauss Syndrome remains to be determined.”
Source :
Current Medicine Group (AZN101636)
Allergy 2009; 64: 589–595
