【medical-news】色甘酸钠有效抑制呼吸道合胞病毒
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Disodium Cromoglycate Active Against Respiratory Syncytial Virus
NEW YORK (Reuters Health) Mar 06 - Disodium cromoglycate, an agent commonly used to prevent bronchial asthma and allergic rhinitis, reduced the symptoms of induced respiratory syncytial virus (RSV) infection in mice, in a study by Japanese researchers reported in the February issue of the Journal of Medical Virology. The results suggest that disodium cromoglycate (DSCG) could be an effective agent for preventing RSV-induced disease and/or relieving the symptoms of RSV infection in humans.
A member of the Pneumovirus genus of the family Paramyxoviridae, RSV causes respiratory-tract infections in patients of all ages and is the leading cause of respiratory failure in young children. Natural infection with RSV does not confer immunity.
The report notes that earlier studies of DSCG's effects on viral infection had been inconsistent. Some research showed that DSCG is a useful adjunct therapy in alleviating asthma symptoms and in preventing colds in adults with asthma, while other research suggested that it is not effective against viral infection either in vitro or in vivo.
Dr. Koichi Hashimoto of Fukushima Medical University and fellow researchers divided a cohort of 8-week-old female BALB/c mice into four groups: RSV-infected and then treated with DSCG; RSV-infected and then treated with saline; mock-infected with RSV and treated with DSCG; and mock-infected with RSV and treated with saline. The groups treated with DSCG received 3, 10 or 30 mg/kg/dose/day.
The mice that received the lower two doses of DSCG were significantly protected from RSV-induced weight loss, compared with the mice that received only sterile saline (p < 0.05).
The mice that received the highest (30 mg/kg/day) dose of DSCG were also protected against weight loss significantly more than those that received 3 mg/kg/day (p < 0.05).
In addition, the study found that although mice treated with DSCG at the time of the RSV inoculation had a decreased lung viral titer on day 1 post-infection versus saline-treated mice, this difference was not maintained.
Based on these findings, along with those from an in vitro portion of the study, the researchers suggest that DSCG inhibits RSV replication in vitro, but acts against RSV by a different mechanism in vivo, possibly through immunomodulatory and anti-inflammatory effects.
J Med Virol 2009;81:354-361.
色甘酸钠有效抑制呼吸道合胞病毒
（纽约路透电）3月6日-2月发行的医学病毒学杂志刊载日本研究人员一项研究报道，色甘酸钠，一种常用于预防支气管哮喘和过敏性鼻炎的药物，减轻小鼠呼吸合胞病毒(RSV)诱发的症状。结果表明，色甘酸钠(DSCG)可能是一种有效的预防RSV引起的疾病和/或减轻人RSV感染症状药物。
作为肺病毒属家族副粘病毒科一名成员，RSV可引起各年龄段患者呼吸道感染，是导致幼儿呼吸衰竭的首位病因。RSV自然感染不产生免疫力.
该报告指出，早先研究DSCG对病毒感染影响结果不一致，一些研究表明，DSCG是一个有用的辅助治疗，减轻哮喘症状、预防成人哮喘患者感冒；而另一些研究表明，无论在体外或在体内DSCG不能有效抗病毒感染。
Fukushima医科大学Koichi Hashimoto博士和研究员将8周龄雌性BALB/c小鼠分为4组：RSV感染后DSCG治疗、RSV感染后生理盐水处理; RSV模拟感染后DSCG处理; RSV模拟感染后生理盐水处理，DSCG剂量：3, 10或30mg/kg/天。
与仅接受生理盐水鼠比，接受两个低剂量DSCG鼠RSV诱发的体重减轻明显减少(p<0.05)。
接受最高剂量(30 mg/kg/天)DSCG小鼠体重减轻程度也较接受3 mg/kg/天鼠显著 减弱(p < 0.05).
此外，研究发现，虽然小鼠RSV接种时DSCG治疗组感染后第1天肺病毒滴度比生理盐水处理的小鼠下降，这种差异并没有保持下去。
基于这些发现，结合体外研究 ，研究人员指出DSCG抑制RSV体外复制，但体内抗RSV作用机制不同，可能通过免疫调节和抗炎作用。
J Med Virol 2009;81:354-361.
NEW YORK (Reuters Health) Mar 06 - Disodium cromoglycate, an agent commonly used to prevent bronchial asthma and allergic rhinitis, reduced the symptoms of induced respiratory syncytial virus (RSV) infection in mice, in a study by Japanese researchers reported in the February issue of the Journal of Medical Virology. The results suggest that disodium cromoglycate (DSCG) could be an effective agent for preventing RSV-induced disease and/or relieving the symptoms of RSV infection in humans.
A member of the Pneumovirus genus of the family Paramyxoviridae, RSV causes respiratory-tract infections in patients of all ages and is the leading cause of respiratory failure in young children. Natural infection with RSV does not confer immunity.
The report notes that earlier studies of DSCG's effects on viral infection had been inconsistent. Some research showed that DSCG is a useful adjunct therapy in alleviating asthma symptoms and in preventing colds in adults with asthma, while other research suggested that it is not effective against viral infection either in vitro or in vivo.
Dr. Koichi Hashimoto of Fukushima Medical University and fellow researchers divided a cohort of 8-week-old female BALB/c mice into four groups: RSV-infected and then treated with DSCG; RSV-infected and then treated with saline; mock-infected with RSV and treated with DSCG; and mock-infected with RSV and treated with saline. The groups treated with DSCG received 3, 10 or 30 mg/kg/dose/day.
The mice that received the lower two doses of DSCG were significantly protected from RSV-induced weight loss, compared with the mice that received only sterile saline (p < 0.05).
The mice that received the highest (30 mg/kg/day) dose of DSCG were also protected against weight loss significantly more than those that received 3 mg/kg/day (p < 0.05).
In addition, the study found that although mice treated with DSCG at the time of the RSV inoculation had a decreased lung viral titer on day 1 post-infection versus saline-treated mice, this difference was not maintained.
Based on these findings, along with those from an in vitro portion of the study, the researchers suggest that DSCG inhibits RSV replication in vitro, but acts against RSV by a different mechanism in vivo, possibly through immunomodulatory and anti-inflammatory effects.
J Med Virol 2009;81:354-361.
色甘酸钠有效抑制呼吸道合胞病毒
（纽约路透电）3月6日-2月发行的医学病毒学杂志刊载日本研究人员一项研究报道，色甘酸钠，一种常用于预防支气管哮喘和过敏性鼻炎的药物，减轻小鼠呼吸合胞病毒(RSV)诱发的症状。结果表明，色甘酸钠(DSCG)可能是一种有效的预防RSV引起的疾病和/或减轻人RSV感染症状药物。
作为肺病毒属家族副粘病毒科一名成员，RSV可引起各年龄段患者呼吸道感染，是导致幼儿呼吸衰竭的首位病因。RSV自然感染不产生免疫力.
该报告指出，早先研究DSCG对病毒感染影响结果不一致，一些研究表明，DSCG是一个有用的辅助治疗，减轻哮喘症状、预防成人哮喘患者感冒；而另一些研究表明，无论在体外或在体内DSCG不能有效抗病毒感染。
Fukushima医科大学Koichi Hashimoto博士和研究员将8周龄雌性BALB/c小鼠分为4组：RSV感染后DSCG治疗、RSV感染后生理盐水处理; RSV模拟感染后DSCG处理; RSV模拟感染后生理盐水处理，DSCG剂量：3, 10或30mg/kg/天。
与仅接受生理盐水鼠比，接受两个低剂量DSCG鼠RSV诱发的体重减轻明显减少(p<0.05)。
接受最高剂量(30 mg/kg/天)DSCG小鼠体重减轻程度也较接受3 mg/kg/天鼠显著 减弱(p < 0.05).
此外，研究发现，虽然小鼠RSV接种时DSCG治疗组感染后第1天肺病毒滴度比生理盐水处理的小鼠下降，这种差异并没有保持下去。
基于这些发现，结合体外研究 ，研究人员指出DSCG抑制RSV体外复制，但体内抗RSV作用机制不同，可能通过免疫调节和抗炎作用。
J Med Virol 2009;81:354-361.
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