【科普】哮喘超重患者皮质激素效价减低
发布于 2008-10-16 · 浏览 1264 · IP 安徽安徽
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Corticosteroids ‘less effective’ in overweight asthmatics
Published date : 01 Oct 2008
MedWire News: Corticosteroids are substantially less effective in overweight and obese asthmatic patients than in those of normal weight, US researchers report.
“This study identifies what could be a significant issue for the 20 million Americans with asthma; specifically, the main controller medication might be less effective if you are overweight or obese,” said E Rand Sutherland (National Jewish Health, Denver, Colorado), lead author of the study.
Previous studies have suggested a link between weight and response to corticosteroids in asthmatics. To investigate further, Sutherland and colleagues enrolled 45 nonsmoking adults, 33 of whom had asthma, and measured their responses to dexamethasone inhalation.
The researchers found that MAP kinase phosphatase-1 (MKP-1) expression, which is essential for corticosteroid action, was increased to a significantly greater extent in airway and peripheral blood cells from normal-weight asthmatics compared with overweight/obese (body mass index [BMI] ≥25 kg/m2) patients, at a 5.27-fold and 3.11-fold increased protein/mRNA level, respectively.
In addition, regression analysis revealed a 0.16-fold decrease in dexamethasone-induced MKP-1 per unit BMI increase in asthmatics. This negative relationship between weight and response to corticosteroids did not occur in participants who did not have asthma.
“Steroids were clearly less effective in overweight and obese asthma patients,” said Sutherland.
“It is important to note, however, that inhaled steroids are still effective in overweight and obese asthmatics, and if patients are concerned that their asthma controller medication is not working, they should discuss this with their physician rather than simply quit taking their medication or increase their prescribed dosage,” he adds.
Sutherland concluded: “These findings should spur doctors to carefully evaluate response to treatment in overweight and obese asthmatics and consider optimizing therapeutic regimens as indicated. We also hope they will spur additional research into the treatment of obese patients with asthma.”
Published date : 01 Oct 2008
MedWire News: Corticosteroids are substantially less effective in overweight and obese asthmatic patients than in those of normal weight, US researchers report.
“This study identifies what could be a significant issue for the 20 million Americans with asthma; specifically, the main controller medication might be less effective if you are overweight or obese,” said E Rand Sutherland (National Jewish Health, Denver, Colorado), lead author of the study.
Previous studies have suggested a link between weight and response to corticosteroids in asthmatics. To investigate further, Sutherland and colleagues enrolled 45 nonsmoking adults, 33 of whom had asthma, and measured their responses to dexamethasone inhalation.
The researchers found that MAP kinase phosphatase-1 (MKP-1) expression, which is essential for corticosteroid action, was increased to a significantly greater extent in airway and peripheral blood cells from normal-weight asthmatics compared with overweight/obese (body mass index [BMI] ≥25 kg/m2) patients, at a 5.27-fold and 3.11-fold increased protein/mRNA level, respectively.
In addition, regression analysis revealed a 0.16-fold decrease in dexamethasone-induced MKP-1 per unit BMI increase in asthmatics. This negative relationship between weight and response to corticosteroids did not occur in participants who did not have asthma.
“Steroids were clearly less effective in overweight and obese asthma patients,” said Sutherland.
“It is important to note, however, that inhaled steroids are still effective in overweight and obese asthmatics, and if patients are concerned that their asthma controller medication is not working, they should discuss this with their physician rather than simply quit taking their medication or increase their prescribed dosage,” he adds.
Sutherland concluded: “These findings should spur doctors to carefully evaluate response to treatment in overweight and obese asthmatics and consider optimizing therapeutic regimens as indicated. We also hope they will spur additional research into the treatment of obese patients with asthma.”
最后编辑于 2022-10-09 · 浏览 1264
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